115889-70-8Relevant academic research and scientific papers
On the Synthesis of Optically Pure Monofluoro cyclohexanol Derivatives by the Fluorinated Sulfoxide Chiron Route
Arnone, Alberto,Bravo, Pierfrancesco,Frigerio, Massimo,Viani, Fiorenza,Cavicchio, Giancarlo,Crucianelli, Marcello
, p. 12361 - 12374 (1994)
Monofluorocyclohexanols 1 are obtained in optically pure form through radical cyclization of gem-chlorofluoroheptenols 2 which derive from the condensation of α-lithium derivative of sulfoxide of 3 on racemic ethyl chlorofluoroacetate 4, and hydride-promo
NEW CHIRONS FOR THE SYNTHESIS OF FLUORINE-CONTAINING COMPOUNDS. AN EFFICIENT ENTRANCE TO α-MONO- AND POLY-FLUORO KETONES HAVING A CHIRAL α'-SULPHINYL SUBSTITUENT
Bravo, Pierfrancesco,Piovosi, Elena,Resnati, Giuseppe,Munari, Sergio De
, p. 115 - 122 (2007/10/02)
The lithium derivatives of optically pure alkyl p-tolyl sulphoxides, having both the R and S absolute configurations at the sulphur atom, have been condensed with the esters of mono- and poly-fluorocarboxylic acids to give several mono- and poly-fluoro ketones with a chiral sulphinyl substituent.The compounds having an alkyl residue on the α or α' position of the ketone group have also been obtained through alkylation of the di-, or mono-anion of the unsubstituted terms.Products chiral only at the sulphur atom, at the sulphur and the fluorinated carbon atom, or at the sulphur and the sulphinyl-substituted carbon have been obtained as single pure enantiomers.
