115889-90-2

Upstream product

• 556-64-9 methyl thiocyanate 
• 766473-59-0 1-(4-fluorophenyl)-2-(methylamino)ethanone 
• 1015445-75-6 4-(4-fluorophenyl)-1-methyl-1,3-dihydro-2H-imidazole-2-thione 
• 74-88-4 methyl iodide 
• 456-00-8 2-amino-4'-fluoroacetophenone hydrochloride 
• 93103-15-2 4-(4-fluorophenyl)-1,3-dihydro-2H-imidazole-2-thione 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1015445-80-3 5-bromo-4-(4-fluorophenyl)-1-methyl-2-(methylsulfanyl)-1H-imidazole 
• 1346175-24-3 4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfonyl)-1H-imidazol-5-yl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 115859-13-7 1-methyl-2-(methylthio)-4-(4-fluorophenyl)-5-(1-carbethoxy-1,4-dihydro-4-pyridyl)imidazole 

Relevant academic research and scientific papers

Regiospecific and highly flexible synthesis of 1,4,5-trisubstituted 2-sulfanylimidazoles from structurally diverse ethanone precursors

Imidazoles represent important bioactive scaffolds in medicinal chemistry. More than 2,500 structures are listed in drug discovery databases and over 3,000 patents have been claimed for imidazole-based structures. Recent imidazole pharmacophores have targ

Synthetic and Mechanistic Studies on the Preparation of Pyridyl-Substituted Imidazothiazoles

A new method is presented for the introduction of the 4'-pyridyl substituent into 6-aryl-2,3-dihydroimidazothiazoles.The method involves treatment of the imidazothiazolines with the reactive complex of pyridine and ethyl chloroformate and oxidative deethyl carboxylation of the dihydropyridine adducts formed.Sulfur in refluxing mesitylene was found most suitable for the latter reaction, but chromium trioxide in pyridine or KtBuO and air were also effective.