115896-71-4Relevant academic research and scientific papers
Efficient and convenient synthesis of β-vinyl sulfides in nickel-catalyzed regioselective addition of thiols to terminal alkynes under solvent-free conditions
Ananikov, Valentine P.,Orlov, Nikolay V.,Beletskaya, Irina P.
, p. 1970 - 1977 (2006)
A new nanosized catalytic system has been developed for convenient preparation of β-vinyl sulfides H2C=C(SAr)R with high yields (79-98%) and excellent selectivity (>98:2). Inexpensive and easily available Ni(acac)2 was used as catalyst precursor. Solvent-free conditions were combined with high atom efficiency of the ArSH addition reaction to terminal alkynes (HC=C-R) in order to create an environmentally friendly synthetic procedure. The mechanistic study has indicated that catalytic reaction takes place under heterogeneous conditions with alkyne insertion into the Ni-S bond as a key step.
