1159096-75-9Relevant articles and documents
A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties
Moss, Neil,Choi, Younggi,Cogan, Derek,Flegg, Adam,Kahrs, Andreas,Loke, Pui,Meyn, Orietta,Nagaraja, Raj,Napier, Spencer,Parker, Ashley,Thomas Peterson,Ramsden, Philip,Sarko, Christopher,Skow, Donna,Tomlinson, Josh,Tye, Heather,Whitaker, Mark
scheme or table, p. 2206 - 2210 (2009/12/07)
We have been exploring the potential of 5-HT2B antagonists as a therapy for chronic heart failure. To assess the potential of this therapeutic approach, we sought compounds possessing the following attributes: (a) potent and selective antagonis