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115913-73-0

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115913-73-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 115913-73-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,1 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115913-73:
(8*1)+(7*1)+(6*5)+(5*9)+(4*1)+(3*3)+(2*7)+(1*3)=120
120 % 10 = 0
So 115913-73-0 is a valid CAS Registry Number.

115913-73-0Relevant articles and documents

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

Herdewijn,Balzarini,Baba,Pauwels,Van Aerschot,Janssen,De Clerq

, p. 2040 - 2048 (2007/10/02)

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.

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