115918-63-3Relevant articles and documents
Synthesis of 14C-labeled copolymers for drug delivery studies
Rhee,Reist,Rock
, p. 173 - 178 (2007/10/02)
14C-labeled polyanhydride copolymers [(20:80/1,3-bis(p-carboxyphenoxy)-propane (CCP):sebacic acid (SA)] (7 and 13) were synthesized according to schemes I and II: 14C-labeled sebacic acid (2,9-14C2) (5) and 14C-labeled CPP 1,3-bis(p-carboxyphenoxy)-propane (labeled at C-1, C-3 of the propyl group) (11) were transformed to the corresponding mixed anhydrides (6 and 12) as prepolymers respectively by reaction with acetic anhydride. The labeled mixed anhydride prepolymers (6 and 12) were condensed with unlabeled counter-prepolymers (12' and 6') to give the labeled polyanhydride copolymers (7 and 13). The labeled copolymers (7 and 13) were identified and characterized by gel permeation chromatography (GPC).