1159187-59-3

Basic information

• Product Name: 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine
• Synonyms: 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine
• CAS NO: 1159187-59-3
• Molecular Weight: 187.244
• Mol File: 1159187-59-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine(1159187-59-3)
• EPA Substance Registry System: 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine(1159187-59-3)

Safety Data

• Hazardous Substances Data: 1159187-59-3(Hazardous Substances Data)

Upstream product

• 27243-91-0 1-(p-methylphenyl)-1-cyanoacetone 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 5720-05-8 4-methylphenylboronic acid 
• 81542-52-1 C₄H₆IN₃ 
• 110580-44-4 4-Chloro-5-methyl-1H-pyrazol-3-ylamine 
• 1780-72-9 4-bromo-5-methyl-1H-pyrazol-3-amine 

Downstream Products

• 1415678-62-4 C₁₇H₁₉N₃O 
• 1415678-63-5 C₂₀H₁₇N₃O 
• 1415678-64-6 C₁₅H₁₂F₃N₃O 
• 1415678-65-7 C₁₆H₁₇N₃O 
• 1415678-66-8 C₁₈H₁₉N₃O 
• 900296-51-7 C₁₉H₂₅N₅ 
• 958712-89-5 C₂₀H₂₇N₅ 
• 1415678-29-3 C₂₀H₂₇N₅ 
• 1415678-43-1 C₂₁H₂₉N₅ 
• 1415678-44-2 C₂₁H₂₇N₅ 
• 1415678-45-3 C₂₃H₃₁N₅ 
• 900874-13-7 C₂₀H₂₅N₅ 
• 1415678-46-4 C₁₉H₂₄N₄O 
• 1415678-47-5 C₂₂H₂₈N₄ 

Relevant articles and documents

The Suzuki-Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction

The efficient Suzuki-Miyaura cross-coupling reaction of halogenated aminopyrazoles and their amides or ureas with a range of aryl, heteroaryl, and styryl boronic acids or esters has been developed. The method allowed incorporation of problematic substrates: aminopyrazoles bearing protected or unprotected pyrazole NH, as well as the free amino or N-amide group. Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura reaction revealed that Br and Cl derivatives were superior to iodopyrazoles, as a result of reduced propensity to dehalogenation. Moreover, the mechanism and factors affecting the undesired dehalogenation side reaction were revealed.