27243-91-0

Usage

Chemical Category

Ketones

Molecular Weight

161.2 g/mol

Physical State

Colorless to light yellow liquid at room temperature

Solubility

Soluble in organic solvents

Applications

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Chemical Reactions

a. Addition of nucleophiles to the cyano group
b. Reduction of the carbonyl group to form corresponding alcohols

Safety Precautions

Hazardous if not properly managed; caution should be taken when handling and storing

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 24851-20-5 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine 
• 1013061-48-7 trans-3-(methoxyimino)-2-(p-tolyl)butanenitrile 
• 925007-44-9 3-methyl-4-(4-methylphenyl)-1,2-oxazol-5-amine 
• 1159187-59-3 3-methyl-4-(4-methylphenyl)-1H-pyrazol-5-amine 
• 1415678-33-9 C₂₂H₂₃N₅ 
• 1415678-66-8 C₁₈H₁₉N₃O 
• 1415678-65-7 C₁₆H₁₇N₃O 
• 1415678-64-6 C₁₅H₁₂F₃N₃O 
• 1415678-63-5 C₂₀H₁₇N₃O 
• 1415678-62-4 C₁₇H₁₉N₃O 
• 1415678-61-3 C₁₆H₁₇N₃O 
• 1415678-60-2 C₁₅H₁₅N₃O 
• 1415678-32-8 C₁₉H₂₂F₃N₅ 
• 1415678-31-7 C₂₄H₂₇N₅ 

Relevant academic research and scientific papers

Stereoselective C?C Oxidative Coupling Reactions Photocatalyzed by Zwitterionic Ligand Capped CsPbBr3 Perovskite Quantum Dots

Semiconductor quantum dots (QDs) have attracted tremendous attention in the field of photocatalysis, owing to their superior optoelectronic properties for photocatalytic reactions, including high absorption coefficients and long photogenerated carrier lifetimes. Herein, by choosing 2-(3,4-dimethoxyphenyl)-3-oxobutanenitrile as a model substrate, we demonstrate that the stereoselective (>99 %) C?C oxidative coupling reaction can be realized with a high product yield (99 %) using zwitterionic ligand capped CsPbBr3 perovskite QDs under visible light illumination. The reaction can be generalized to different starting materials with various substituents on the phenyl ring and varied functional moieties, producing stereoselective dl-isomers. A radical mediated reaction pathway has been proposed. Our study provides a new way of stereoselective C?C oxidative coupling via a photocatalytic means using specially designed perovskite QDs.

N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

NF-κB-inducing kinase (NIK), an oncogenic drug target that is associated with various cancers, is a central signalling component of the non-canonical pathway. A blind screening process, which established that amino pyrazole related scaffolds have an effect on IKKbeta, led to a hit-to-lead optimization process that identified the aminopyrazole 3a as a low μM selective NIK inhibitor. Compound 3a effectively inhibited the NIK-dependent activation of the NF-κB pathway in tumour cells, confirming its selective inhibitory profile.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.