115929-62-9Relevant academic research and scientific papers
A formal synthesis of lavendamycin methyl ester, nitramarine, and their analogues: A povarov approach
Ramesh, Subburethinam,Nagarajan, Rajagopal
, p. 545 - 558 (2013/03/14)
A convergent formal synthesis of lavendamycin methyl ester and synthesis of its analogues have been delineated through the Povarov approach. This protocol is also applied to the formal synthesis of nitramarine (3) in good yield.
An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride
Chandrappa,Vinaya,Ramakrishnappa,Rangappa
experimental part, p. 3019 - 3022 (2011/03/17)
A novel, efficient Fe/CaCl2 system is revealed for the reduction of nitroarenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation (CTH). The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, methyl, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple experimental procedure and easy purification make the protocol advantageous
Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation
Gamble, Allan B.,Garner, James,Gordon, Christopher P.,O'Conner, Sean M. J.,Keller, Paul A.
, p. 2777 - 2786 (2008/02/12)
The selective reduction of aryl nitro compounds in the presence of sensitive functionalities, including halide, carbonyl, nitrile, and ester substituents, under ultrasonic irradiation at 35 kHz is reported in yields of 39-98%. Iron powder proved superior to stannous chloride with high tolerance of sensitive functional groups and high yields of the desired aryl amines in relatively short reaction times. Simple experimental procedure and purification also make the iron reduction of aryl nitro compounds advantageous over other methods of reduction. Copyright Taylor & Francis Group, LLC.
Total synthesis of herbimycin A
Canova, Sophie,Bellosta, Veronique,Bigot, Antony,Mailliet, Patrick,Mignani, Serge,Cossy, Janine
, p. 145 - 148 (2007/10/03)
(Chemical Equation Presented) Hsp90 has recently emerged as a promising biological target for treatment of cancer. Herbimycin A and other members of the benzoquinoid ansamycin class of natural products are known to inhibit Hsp90 activity. The total synthesis of herbimycin A was achieved from the commercially available Roche ester 1 by using allylmetals to control the stereogenic centers at C6, C7, C10, C11, and C12 and a ring-closing metathesis to control the (Z)-double bond of the (E,Z)-dienic moiety.
Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I
Coutts,Kallmerten
, p. 4305 - 4308 (2007/10/02)
Convergent synthesis of (±)-2, a key intermediate in the Merck synthesis of macbecin I (1), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the
