1568-70-3

Basic information

• Product Name: 4-Methoxy-2-nitrophenol
• Synonyms: 4-METHOXY-2-NITROPHENOL;4-HYDROXY-3-NITROANISOLE;3-NITROHYDROQUINONE MONO-METHYL ETHER;TIMTEC-BB SBB008447;4-METHOXY-2-NITROPHENOL, TECH.;4-Methoxy-2-nitrophenol,98%;4-Methoxy-2-nitrophenol,99+%;4-Methoxy-2-nitrophenol≥ 98% (GC)
• CAS NO: 1568-70-3
• Molecular Formula: C₇H₇NO₄
• Molecular Weight: 169.13
• Product Categories: Aromatic Phenols;Phenoles and thiophenoles;Organic Building Blocks;Oxygen Compounds;Phenols;Isoquinolines ,Quinolines ,Quinaldines
• Mol File: 1568-70-3.mol
• Article Data: 62

Chemical Properties

• Melting Point: 78-80 °C(lit.)
• Boiling Point: 298.4°C (rough estimate)
• Flash Point: 128.663 °C
• Appearance: orange-brown powder and chunks
• Density: 1.3375 (estimate)
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.5830 (rough estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Soluble in methanol almost transparency.
• PKA: 7.33±0.14(Predicted)
• CAS DataBase Reference: 4-Methoxy-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-2-nitrophenol(1568-70-3)
• EPA Substance Registry System: 4-Methoxy-2-nitrophenol(1568-70-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 1568-70-3(Hazardous Substances Data)

Usage

Chemical Properties

orange-brown powder and chunks

Uses

4-Methoxy-2-nitrophenol can treat obesity, prevent weight gain, promote weight loss, promote slimming, or treat or prevent the development of diabetes.

InChI:InChI=1/C7H7NO4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3/p-1

Synthetic route

4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With dimethylbromosulphonium bromide; tetrabutylammonium nitrite In acetonitrile at 20℃; for 1.25h; regioselective reaction;	95%
With trichloroisocyanuric acid; bismuth subnitrate/charcoal In dichloromethane at 20℃; for 0.5h; regioselective reaction;	95%
With 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imide at 20℃; for 2h; Ionic liquid;	95%

1,4-dimethoxy-2-nitrobenzene (89-39-4) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
Stage #1: 1,4-dimethoxy-2-nitrobenzene With aluminum (III) chloride In chloroform at 60℃; for 2.5h; Stage #2: With hydrogenchloride; water In chloroform at 20℃; regioselective reaction;	93%
With quinoline; lithium iodide at 160 - 170℃; for 0.25h;	88%
With potassium hydroxide

p-cresol (106-44-5) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With nickel ammonium sulfate; nitric acid In chloroform; water at 20℃; for 3h;	93%

2,3,5,6-tetrabromo-4-methyl-4-nitrocyclohexa-2,5-dien-1-one (95111-49-2) + 4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3) + tetrabromo-p-cresol (37721-75-8) + 2,3,5-tribromo-4-methyl-6-nitrophenol (105590-20-3) + p-benzoquinone (106-51-4)

Conditions	Yield
In acetone at -50 - 30℃; Mechanism; phenol;	A 40% B 70% C 30% D 8%

4-bromo-3-nitroanizole (5344-78-5) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 50℃; for 22h;	70%

4-methoxy-2-nitroaniline (96-96-8) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With water; sodium hydroxide at 100℃; for 4h;	63%
With potassium hydroxide
With sodium hydroxide; P2 O5 In water

4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3) + 4-methoxy-2,6-dinitrophenol (3410-94-4)

Conditions	Yield
With Eu-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;	A 4% B 63%
With Yb-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;	A 50% B 26%

tert.-butylnitrite (540-80-7) + 4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With water In tetrahydrofuran at 25℃; for 2.5h; Schlenk technique;	62%

p-methoxyl benzaldoxime (3717-21-3, 3717-22-4, 140461-28-5, 140461-29-6, 3235-04-9) → 4-methoxy-2-nitrophenol (1568-70-3) + (p-methoxyphenyl)nitromethane (29559-26-0) + 4-methoxybenzoic acid (100-09-4)

Conditions	Yield
With sodium perborate tetrahydrate; acetic acid at 20 - 60℃;	A 6% B 44% C 10%
With sodium peroxoborate tetrahydrate; acetic acid at 60℃;	A 6% B 44% C 10%

4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3) + p-benzoquinone (106-51-4)

Conditions	Yield
With oxygen; cis-nitrous acid In water at 23℃; pH=2.3; Kinetics; pH-value; Reagent/catalyst; Darkness;	A 41% B 27%
With hydrogenchloride; air; cis-nitrous acid at 25℃; Rate constant; Mechanism; Product distribution; μ= 1.0 mol dm3- (NaCl), var. conc. of HNO2, HCl (or H2SO4), and oxygen/NO;

5-hydroxy-2-methoxy-4-nitrobenzaldehyde → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With palladium diacetate In cyclohexane at 140℃; for 20h; Molecular sieve; Sealed tube;	14%

4-methoxybenzenediazonium tetrafluoroborate (459-64-3) + disodium salt of the dianion of 1,4-dinitrocyclooctatetraene → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
Further byproducts given;	6%

1,4-dimethoxy-2-nitrobenzene (89-39-4) → 4-methoxy-2-nitrophenol (1568-70-3) + 2-nitrohydroquinone (16090-33-8)

Conditions	Yield
With hydrogen bromide

p-tert-butoxyanisole (15360-00-6) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With nitric acid; acetic acid; propionic acid at -10 - 5℃; Behandeln der Reaktionsprodukte mit konz. wss. HCl und Essigsaeure bei 16grad bzw. bei 100grad;

p-tert-butoxyanisole (15360-00-6) → 4-methoxy-2-nitrophenol (1568-70-3) + 4-hydroxy-2-nitroanisole (15174-02-4)

Conditions	Yield
With nitric acid; acetic acid; propionic acid at -10 - 5℃; Behandeln der Reaktionsprodukte mit konz. wss. HCl und Essigsaeure bei 16grad oder bei 100grad;

p-Isopropoxyphenyl methyl ether (20744-02-9) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With nitric acid; acetic acid; propionic acid at -10 - 5℃; Behandeln der Reaktionsprodukte mit konz. wss. HCl und Essigsaeure bei 16grad bzw. bei 100grad;

p-Isopropoxyphenyl methyl ether (20744-02-9) → 4-methoxy-2-nitrophenol (1568-70-3) + 4-hydroxy-2-nitroanisole (15174-02-4)

Conditions	Yield
With nitric acid; acetic acid; propionic acid at -10 - 5℃; Behandeln der Reaktionsprodukte mit konz. wss. HCl und Essigsaeure bei 16grad oder bei 100grad;

4-methoxy-2-nitroacetanilide (119-81-3) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With sodium hydroxide

2-hydroxy-5-methoxy-3-nitrobenzoic acid (2888-01-9) + aniline (62-53-3) → 4-methoxy-2-nitrophenol (1568-70-3)

2-nitrohydroquinone (16090-33-8) + methyl iodide (74-88-4) → 4-methoxy-2-nitrophenol (1568-70-3) + 1,4-dimethoxy-2-nitrobenzene (89-39-4)

Conditions	Yield
With potassium carbonate at 100℃; im geschlossenen Rohr;

para-methoxynitrobenzene (100-17-4) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With sodium hydroxide Irradiation;

4-methoxy-phenol (150-76-5) → 4-methoxy-2-nitrophenol (1568-70-3) + 4-methoxycatechol (3934-97-2)

Conditions	Yield
With sodium peroxynitrite In phosphate buffer at 20 - 25℃; pH=7.0; Kinetics; Further Variations:; Solvents; Nitration; hydroxylation;

4-methoxy-2-nitroaniline (96-96-8) + aqueous KOH-solution → 4-methoxy-2-nitrophenol (1568-70-3)

1,4-dimethoxy-2-nitrobenzene (89-39-4) + aqueous-alcoholic KOH-solution → 4-methoxy-2-nitrophenol (1568-70-3)

p-Isopropoxyphenyl methyl ether (20744-02-9) + nitric acid (7697-37-2) + acetic acid (64-19-7) + propionic acid (802294-64-0) → 4-methoxy-2-nitrophenol (1568-70-3) + 4-hydroxy-2-nitroanisole (15174-02-4)

Conditions	Yield
at 0 - 5℃; Erwaermen des Reaktionsprodukts mit konz. wss. HCl und Essigsaeure;

4-methoxy-3-nitroaniline (577-72-0) + water (7732-18-5) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With potassium hydroxide

methanol (67-56-1) + methyl 2-nitro-4-methoxyphenyl phosphate (1028591-92-5) → dimethylphosphoric acid (813-78-5) + 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
With tert-butylammonium hydroxide; 1,3-bis-N1-(1,5,9-triazacyclododecyl)propane*Zn(II)*MeOH at 25℃; Kinetics;

2,5-dimethoxy-4-nitrobenzaldehyde (1207-59-6) → 4-methoxy-2-nitrophenol (1568-70-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / 40 h / 50 °C 2: palladium diacetate / cyclohexane / 20 h / 140 °C / Molecular sieve; Sealed tube View Scheme

4-methoxy-2-nitroaniline (96-96-8) → 5-methoxy-benzo[1,2,5]oxadiazole (4413-48-3) + 3-nitroanisole (555-03-3) + 4-methoxy-2-nitrophenol (1568-70-3) + 4-methoxy-[1,2]benzoquinone (69818-23-1) + 4-methoxycatechol (3934-97-2)

Conditions	Yield
With ferrous(II) sulfate heptahydrate; dihydrogen peroxide at 25℃; for 0.0166667h; pH=6.12; Kinetics; pH-value;

4-methoxy-2-nitrophenol (1568-70-3) → 2-amino-4-methoxyphenol hydrochloride (32190-97-9)

Conditions	Yield
With hydrogen; palladium on activated carbon In methanol for 4h;	100%

4-methoxy-2-nitrophenol (1568-70-3) → 2-amino-4-methoxyphenol (20734-76-3)

Conditions	Yield
With palladium on activated carbon; hydrogen In methanol; water for 40h;	99%
With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 1810.02 Torr; for 0.333333h;	98%
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 24h;	97.3%

4-methoxy-2-nitrophenol (1568-70-3) + ethyl bromoacetate (105-36-2) → ethyl 2-[4-methoxy-2-nitrophenoxy]acetate (109364-95-6)

Conditions	Yield
Stage #1: 4-methoxy-2-nitrophenol With potassium hydroxide In ethanol for 1h; Stage #2: ethyl bromoacetate In N,N-dimethyl-formamide for 24h; Further stages.;	99%
With potassium carbonate In acetone Reflux;	85%
With potassium carbonate In acetone for 12h; Reflux;	85%

4-methoxy-2-nitrophenol (1568-70-3) + trifluoromethanesulfonic acid anhydride (1025373-45-8) → Trifluoromethanesulfonic acid 4-methoxy-2-nitrophenyl ester (213596-32-8)

Conditions	Yield
With pyridine; hydrogenchloride In dichloromethane; water	99%

Cyclohexyl isocyanide (931-53-3) + 4-methoxy-2-nitrophenol (1568-70-3) + propionaldehyde (123-38-6) + 4-chlorobenzylamine (104-86-9) → 2-(N-(4-chlorobenzyl)-N-(4-methoxy-2-nitrophenyl)amino)-N-cyclohexylbutanamide

Conditions	Yield
In methanol at 60℃; for 72h;	98%
In methanol at 60℃; Ugi-Smiles coupling;	98%

4-methoxy-2-nitrophenol (1568-70-3) + benzyl alcohol (100-51-6) → 5‐methoxy‐2‐phenylbenzo[d]oxazole

Conditions	Yield
With Au NCs/TiO2 In toluene at 130℃; for 24h; Inert atmosphere;	97%
With 1,1'-bis-(diphenylphosphino)ferrocene In toluene at 150℃; for 24h; Inert atmosphere;	83%

4-methoxy-2-nitrophenol (1568-70-3) + prenyl bromide (870-63-3) → 4-methoxy-1-(3'-methylbut-2'-enyloxy)-2-nitrobenzene

Conditions	Yield
With potassium carbonate In acetone Heating;	96%
With potassium carbonate In acetone at 65℃; for 12h;

bromo-phenyl-acetic acid methyl ester (37167-62-7) + 4-methoxy-2-nitrophenol (1568-70-3) → methyl 2-(4-methoxy-2-nitrophenoxy)-2-phenylacetate

Conditions	Yield
With potassium carbonate In acetone at 20 - 50℃; for 16h;	96%

4-methoxy-2-nitrophenol (1568-70-3) → 2-bromo-4-methoxy-6-nitrophenol (115929-59-4)

Conditions	Yield
With bromine; potassium bromide In water; acetic acid at 20℃; for 1h;	95%
With bromine; acetic acid; potassium bromide In water at 70℃; for 16h;	89%
With bromine; acetic acid for 1h; Heating;	76%

4-methoxy-2-nitrophenol (1568-70-3) + benzoyl chloride (98-88-4) → 1-benzoyloxy-4-methoxy-2-nitro-benzene

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	94%
With pyridine at 20℃; for 4h;

4-methoxy-2-nitrophenol (1568-70-3) + 4-methoxy-benzoyl chloride (100-07-2) → C15H13NO6 (1290636-85-9)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	92%

4-methoxy-2-nitrophenol (1568-70-3) + cinnamoyl chloride (102-92-1) → 4-methoxy-2-nitrophenyl cinnamate

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	90%

4-methoxy-2-nitrophenol (1568-70-3) + 4-chloro-benzoyl chloride (122-01-0) → C14H10ClNO5 (1290636-86-0)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	89%

4-methoxy-2-nitrophenol (1568-70-3) + 5-methyl-3,4-hexadien-1-ol (54795-27-6) → 4-methoxy-1-((5-methylhexa-3,4-dien-1-yl)oxy)-2-nitrobenzene

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; for 17h; Mitsunobu Displacement; Inert atmosphere;	89%

tetrakis(trimethylphosphine)nickel(0) (28069-69-4) + 4-methoxy-2-nitrophenol (1568-70-3) + oxygen (80937-33-3) → trans-bis(4-methoxy-2-nitrophenolato[O:O])bis(oxotrimethylphosphorane)nickel (226714-29-0)

Conditions	Yield
In diethyl ether byproducts: OPMe3, H2O; absence of air and moisture; exposing mixt. of Ni-complex and substituted phenol to slight excess O2 at -70°C, stirring at 0°C for17 h; removal of volatiles (vac.), extn. into THF, crystn. (THF/ether=5:1, -27°C); elem. anal.;	87%

4-methoxy-2-nitrophenol (1568-70-3) → 2-(2,6-diisopropylphenyl)-6-(4-methoxy-2-nitrophenoxy)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Conditions	Yield
With hydrogenchloride; potassium carbonate; acetic acid	87%

Trimethyl orthoacetate (1445-45-0) + 4-methoxy-2-nitrophenol (1568-70-3) → 5-Methoxy-2-methyl-benzoxazole (5676-57-3)

Conditions	Yield
With indium; acetic acid In benzene for 1h; Inert atmosphere; Reflux;	86%

4-methoxy-2-nitrophenol (1568-70-3) + propargyl bromide (106-96-7) → 5-methoxy-2-(prop-2-ynyloxy)nitrobenzene (63147-85-3)

Conditions	Yield
With potassium carbonate In acetone for 16h; Heating;	85%
With potassium carbonate In acetone Heating;
With potassium carbonate In toluene; acetonitrile at 70℃; Inert atmosphere;

4-methoxy-2-nitrophenol (1568-70-3) + chloroacetone (78-95-5) → 1-(4-methoxy-2-nitrophenoxy)propan-2-one

Conditions	Yield
With sodium hydrogencarbonate; methyl tributylammonium chloride; potassium bromide In water; toluene at 65℃; for 24h;	85%
With potassium carbonate; potassium iodide In acetone at 55℃;

4-methoxy-2-nitrophenol (1568-70-3) + allyl bromide (106-95-6) → 1-(allyloxy)-4-methoxy-2-nitrobenzene

Conditions	Yield
With potassium carbonate In acetonitrile at 70℃; for 24h; Schlenk technique;	84%
With potassium carbonate In acetone at 60℃; for 5h;	76%
With potassium carbonate In acetone at 81℃; for 6h; Schlenk technique;

4-methoxy-2-nitrophenol (1568-70-3) + trimethyl orthoformate (149-73-5) → 5-methoxybenzoxazole

Conditions	Yield
With indium; acetic acid In benzene for 1h; Inert atmosphere; Reflux;	83%

4-methoxy-2-nitrophenol (1568-70-3) → 4-methoxy-2-nitrophenyl sulfurofluoridate

Conditions	Yield
Stage #1: 4-methoxy-2-nitrophenol With potassium fluoride; potassium carbonate; N,N`-sulfuryldiimidazole; trifluoroacetic acid In water; acetonitrile Stage #2: In water; acetonitrile at 20℃; for 18h;	81%

4-methoxy-2-nitrophenol (1568-70-3) + 2,2,2-trifluoroethyl trifluoromethanesulphonate (6226-25-1) → 4-methoxy-2-nitro-1-(2,2,2-trifluoroethoxy)benzene

Conditions	Yield
Stage #1: 4-methoxy-2-nitrophenol With caesium carbonate In dimethyl sulfoxide for 0.0833333h; Cooling with ice; Stage #2: 2,2,2-trifluoroethyl trifluoromethanesulphonate at 20 - 24℃;	81%

4-chloro-6-methylpyrimidine-5-carbonitrile + 4-methoxy-2-nitrophenol (1568-70-3) → 4-(4-methoxy-2-nitrophenoxy)-6-methylpyrimidine-5-carbonitrile

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;	80%

4-methoxy-2-nitrophenol (1568-70-3) + 2-(diethylamino)ethyl chloride (100-35-6) → N,N-diethyl-2-(4-methoxy-2-nitrophenoxy)ethanamine (805192-92-1)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 1.5h; Heating;	78%

4-methoxy-2-nitrophenol (1568-70-3) + phenethyl isocyanide (59795-89-0) + pivalaldehyde (630-19-3) → 2-(4-methoxy-2-nitrophenoxy)-3,3-dimethyl-N-phenethylbutanamide (1558696-36-8)

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 55℃; for 12h; Passerini Condensation; Inert atmosphere;	78%
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 55℃; for 12h; Passerini Condensation;	78%

4-methoxy-2-nitrophenol (1568-70-3) + 2,6-di-tert-butyl-4-methyl-phenol (128-37-0) → 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-methoxybenzoxazole (29078-05-5)

Conditions	Yield
With iron; sulfur In 1,2-dichloro-benzene at 180℃; for 24h; Inert atmosphere;	76%

Upstream product

• 119-81-3 4-methoxy-2-nitroacetanilide 
• 150-76-5 4-methoxy-phenol 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 95111-49-2 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one 
• 96-96-8 4-methoxy-2-nitroaniline 
• 89-39-4 1,4-dimethoxy-2-nitrobenzene 
• 20744-02-9 p-Isopropoxyphenyl methyl ether 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 802294-64-0 propionic acid 
• 106-44-5 p-cresol 
• 3717-21-3 p-methoxyl benzaldoxime 
• 540-80-7 tert.-butylnitrite 
• 1207-59-6 3,6-Dimethoxy-4-nitrobenzaldehyde 

Downstream Products

• 16169-29-2 1-butoxy-4-methoxy-2-nitro-benzene 
• 16169-28-1 4-methoxy-2-nitro-1-propoxy-benzene 
• 18468-36-5 1-methoxy-2-nitro-4-propoxy-benzene 
• 16169-26-9 1-ethoxy-4-methoxy-2-nitro-benzene 
• 115929-59-4 6-bromo-4-methoxy-2-nitrophenol 
• 761440-61-3 4-Methoxy-1-(2-methoxy-ethoxy)-2-nitro-benzene 
• 188407-75-2 2-(4-Methoxy-2-nitro-phenoxy)-2-methyl-malonic acid dimethyl ester 
• 191096-30-7 Dihydro-3-(4-methoxy-2-nitrophenoxy)-2-(3H)-furanone 
• 213596-32-8 Trifluoromethanesulfonic acid 4-methoxy-2-nitrophenyl ester 
• 3934-97-2 4-methoxycatechol 
• 848589-63-9 1-(3-bromo-propoxy)-4-methoxy-2-nitro-benzene 
• 32190-97-9 2-amino-4-methoxyphenol hydrochloride 
• 551001-91-3 2-Iodo-4-methoxy-6-nitro-phenol 

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Due to their remarkable properties, task-specific ionic liquids have turned out to be progressively popular over the last few years in the field of green organic synthesis. Herein, for the first time, we report that a new task-specific nitrite-based ionic liquid such as 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imides (TS-N-IL) derived from biodegradable ethyl nicotinate indeed acted as an efficient and eco-friendly reagent for the synthesis of highly valuable nitroaromatic compounds and drugs including nitroxynil, tolcapone, niclofolan, flutamide, niclosamide and nitrazepam. The bridging of an ionic liquid with nitrite group not only increases the yield and rate of direct C[sbnd]N bond formation reaction but also allows easy product separation and recyclability of a byproduct. Nonvolatile nature, easy synthesis, merely stoichiometric need and mildness are a portion of the extra focal points of TS-N-IL while contrasted with tert-butyl nitrite an outstanding and highly-flammable reagent utilized largely in organic synthesis.

Study on the degradation mechanism and pathway of benzene dye intermediate 4-methoxy-2-nitroaniline: Via multiple methods in Fenton oxidation process

Benzene dye intermediate (BDI) 4-methoxy-2-nitroaniline (4M2NA) wastewater has caused significant environmental concern due to its strong toxicity and potential carcinogenic effects. Reports concerning the degradation of 4M2NA by advanced oxidation process are limited. In this study, 4M2NA degradation by Fenton oxidation has been studied to obtain more insights into the reaction mechanism involved in the oxidation of 4M2NA. Results showed that when the 4M2NA (100 mg L-1) was completely decomposed, the TOC removal efficiency was only 30.70-31.54%, suggesting that some by-products highly recalcitrant to the Fenton oxidation were produced. UV-Vis spectra analysis based on Gauss peak fitting, HPLC analysis combined with two-dimensional correlation spectroscopy and GC-MS detection were carried out to clarify the degradation mechanism and pathway of 4M2NA. A total of nineteen reaction intermediates were identified and two possible degradation pathways were illustrated. Theoretical TOC calculated based on the concentration of oxalic acid, acetic acid, formic acid, and 4M2NA in the degradation process was nearly 94.41-97.11% of the measured TOC, indicating that the oxalic acid, acetic acid and formic acid were the main products. Finally, the predominant degradation pathway was proposed. These results could provide significant information to better understand the degradation mechanism of 4M2NA.