1159411-01-4Relevant articles and documents
Ruthenium(ii)-catalyzed C-H activation/C-N bond formation via in situ generated iminophosphorane as the directing group: Construction of annulated pyridin-2(1H)-ones
Arigela, Rajesh K.,Kumar, Ravi,Joshi, Trapti,Mahar, Rohit,Kundu, Bijoy
, p. 57749 - 57753 (2014)
We describe an efficient and straightforward synthesis of annulated pyridin-2(1H)-ones following condensation of acyl azides with internal alkynes via the ruthenium-catalyzed ortho C-H bond activation. The reaction in DCE proceeds via in situ generation of iminophosphoranes as directing group-coordination of Ru with N-atom-ortho cyclometallation-insertion of an alkyne into the Ru-C bond-protonation-reductive elimination in a domino sequence. The role and stability of in situ generated iminophosphorane and ruling out the possibility for the benzamide involvement was established using 1H and 31P NMR experiments. This journal is
Heterogeneous copper-catalysed cascade reactions of 2-bromobenzamides with β-keto esters leading to isoquinolin-1(2H)-one derivatives
Zhao, Hong,Wu, Yichao,Wei, Tin,Cai, Mingzhong
, p. 634 - 638 (2015/01/09)
The heterogeneous copper-catalysed cascade reaction of 2-bromobenzamides with β-keto esters was achieved in dioxane at 80 °C in the presence of the MCM-41-immobilised bidentate nitrogen copper(I) complex [MCM-41-2N-CuI] with Cs2CO3 as base, affording a variety of isoquinolin-1(2H )-one derivatives in moderate to good yields. This heterogeneous copper catalyst can be recovered by a simple filtration and reused 10 times without significant loss of activity.
