115948-87-3

Basic information

• Product Name: 4-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanoic acid
• Synonyms: 4-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanoic acid;4-(2,4-diketo-1H-quinazolin-3-yl)butyric acid;4-(2,4-dioxo-1H-quinazolin-3-yl)butanoic acid;BB_SC-3323;EU-0060588;MLS000094667;SMR000030220;4-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)butanoic acid
• CAS NO: 115948-87-3
• Molecular Formula: C12H12N2O4
• Molecular Weight: 248.23468
• Mol File: 115948-87-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanoic acid(115948-87-3)
• EPA Substance Registry System: 4-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)butanoic acid(115948-87-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 115948-87-3(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 693226-78-7 4-(2-aminobenzoylamino)butyric acid ethyl ester 
• 10312-35-3 4-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-butyric acid ethyl ester 

Relevant articles and documents

Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent

A series of new quinazolinedione derivatives have been readily synthesized and evaluated for their in vitro antiplasmodial growth inhibition activity. Most of the compounds inhibited P. falciparum FcB1 strain in the low to medium micromolar concentration. The 2-ethoxy 8ag’, 2-trifluoromethoxy 8ai’ and 4-fluoro-2-methoxy 8ak’ showed the best inhibitory activity with EC50 values around 5 μM and were non-toxic to the primary human fibroblast cell line AB943. However, these compounds were less potent than the original hit MMV665916, which showed remarkable growth inhibition with EC50 value of 0.4 μM and presented the highest selectivity index (SI > 250). In addition, a novel approach for determining the docking poses of these quinazolinedione derivatives with their potential protein target, the P. falciparum farnesyltransferase PfFT, was investigated.