1159581-64-2Relevant academic research and scientific papers
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
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Page/Page column 38; 39, (2014/02/16)
The present invention relates to substituted pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
Three-component synthesis of N-boc-4-iodopyrroles and sequential one-pot alkynylation
Merkul, Eugen,Boersch, Christina,Frank, Walter,Mueller, Thomas J.J.
supporting information; experimental part, p. 2269 - 2272 (2009/09/30)
(Hetero)aryl-, alkenyl-, and selected alkyl-substituted acid chlorides can be efficiently coupled with N-Boc-protected propargylamine to produce ynones which are converted in a one-pot fashion to 2-substituted N-Boc-4-iodopyrroles. Upon addition of a furt
