1159683-76-7Relevant academic research and scientific papers
Palladium-Catalyzed Asymmetric Suzuki-Miyaura Cross Coupling with Homochiral Phosphine Ligands Having Tetrahydro-1 H -imidazo[1,5-a ]indole Backbone
Uozumi, Yasuhiro,Matsuura, Yutaka,Suzuka, Toshimasa,Arakawa, Takayasu,Yamada, Yoichi M. A.
, p. 59 - 68 (2016/12/24)
Amphiphilic polystyrene-poly(ethylene glycol) resin-supported chiral imidazoindole phosphines (PS-PEG-L?), (3R,9aS)-2-aryl-3-(2-dialkylphosphino)phenyltetrahydro-1H-imidazo[1,5-a]indol-1-one, bearing PPh2, P(t-Bu)2, and P(c-Hex)2 groups were designed and prepared with a view toward using them in aqueous heterogeneous asymmetric Suzuki-Miyaura biaryl coupling. The asymmetric coupling of 2-substituted 1-iodonaphthalenes and 2-substituted naphthalen-1-ylboronic acid took place in water under heterogeneous conditions in the presence of 10 mol% palladium of PS-PEG-L?-Pd complexes to give up to 94% ee of (S)-2,2′-disubstituted 1,1′-binaphthyls.
Enantioselective carbenoid insertion into phenolic O-H bonds with a chiral copper(I) imidazoindolephosphine complex
Osako, Takao,Panichakul, Duanghathai,Uozumi, Yasuhiro
, p. 194 - 197 (2012/02/16)
The enantioselective O-H carbenoid insertion reaction with a new chiral copper(I) imidazoindolephosphine complex has been developed. The chiral copper(I) complex catalyzed the insertion of carbenoids derived from α-diazopropionates into the O-H bonds of various phenol derivatives to give the corresponding α-aryloxypropionates with up to 91% ee.
