115983-78-3

Basic information

• Product Name: 2-Propenoyl isocyanate, 3-ethoxy-, (2E)-
• CAS NO: 115983-78-3
• Molecular Formula: C6H7NO3
• Molecular Weight: 141.126
• Mol File: 115983-78-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 2-Propenoyl isocyanate, 3-ethoxy-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl isocyanate, 3-ethoxy-, (2E)-(115983-78-3)
• EPA Substance Registry System: 2-Propenoyl isocyanate, 3-ethoxy-, (2E)-(115983-78-3)

Safety Data

• Hazardous Substances Data: 115983-78-3(Hazardous Substances Data)

Upstream product

• 6191-99-7 3-ethoxyacryloyl chloride 
• 3315-16-0 silver cyanate 
• 6192-01-4 (E)-3-ethoxyprop-2-enoic acid 
• 144874-96-4 (E)-4-ethoxy-2-oxo-3-butenoyl chloride 
• 27738-96-1 chlorocarbonyl isocyanate 
• 109-92-2 ethyl vinyl ether 
• 6191-99-7 (2E)-3-ethoxyprop-2-enoyl chloride 

Downstream Products

• 227084-04-0 1-((E)-3-Ethoxy-acryloyl)-3-[(2S,3R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-urea 
• 928778-07-8 benzoic acid 4-[3-(3-ethoxyacryloyl)-ureido]-3,3-difluoro-tetrahydro-thiophen-2-ylmethyl ester 
• 928778-08-9 benzoic acid 4-[3-(3-ethoxyacryloyl)-ureido]-3,3-difluoro-tetrahydro-thiophen-2-ylmethyl ester 
• 1069040-55-6 (1R,2S,5S,3R,4R)-1-(3-ethoxyacryloyl)carbamoylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane 
• 1145778-45-5 (2S,4R,E)-benzyl 2-(benzoyloxymethyl)-4-(3-(3-ethoxyacryloyl)ureido)-3,3-difluoropyrrolidine-1-carboxylate 
• 1145778-30-8 (2R,4S,E)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-4-(3-(3-ethoxyacryloyl)ureido)-3,3-difluoropyrrolidine-1-carboxylate 
• 227084-00-6 1-((E)-3-Ethoxy-acryloyl)-3-[(2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl]-urea 
• 190195-78-9 1-((1S,3S,4R,5S)-3-Benzyloxy-4-benzyloxymethyl-bicyclo[3.1.0]hex-1-yl)-3-((E)-3-ethoxy-acryloyl)-urea 
• 161452-69-3 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol 
• 161452-70-6 (2R,3R)-1,4-anhydro-5-O-benzyl-3-C-benzyloxymethyl-2,3-dideoxy-2--D-arabitol 
• 160999-12-2 N-<<<(2S,4S)-2-(O-benzoylmethyl)tetrahydrofuranyl>amino>carbonyl>-3-ethoxy-2-propenamide 
• 143643-10-1 Benzoic acid (1R,2R,4R)-2-benzyloxymethyl-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester 
• 115983-79-4 (-)-N-<<<(1R,4R,5S)-3-<(benzyloxy)methyl>-4,5-(isopropylidenedioxy)-2-cyclopentenyl>amino>carbonyl>-3-ethoxy-2-propenamide 

Relevant articles and documents

Heterocyclic analogs of nucleosides: Synthesis and biological evaluation of some 1-(3-thianyl)uracil and 9-(3-thianyl)adenine derivatives

The 1-(3-thianyl)uracil (9) and 9-(3-thianyl)adenine (14) nucleoside analogs have been prepared from the key intermediate, (±)-(3β,5β)-3-amino-5-(hydroxymethyl)thinae (6). Analog 9 was converted into a mixture of diastereomeric sulfoxides (10) that afforded, by a Pummerer reaction, a mixture of (±)-1-{(2'β,3'β,5'β)-2'-acetoxy-5'-(acetoxymethyl)thian-3'-yl}2, 4(1H,3H)-pyrimidinedione (11a) and its 6'-β isomer (11b). The EI mass spectra of the nucleoside analogs are discussed. The uracil nucleoside analogs have been evaluated also for their anti-HIV and antitumor activities.

Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates

The synthesis of both 2?-hydroxy-3?-deoxy and 2?-deoxy-3?-hydroxy cyclopentyl nucleoside phosphonates with the natural nucleobases adenine, thymine, cytosine and guanine from a single precursor has been performed. The guanine containing analogues showed antiviral activity. Especially the 3?-deoxy congener 23 was active, displaying an EC50 of 5.35 μM against TK+ VZV strain and an EC50 of 8.83 μM against TK? VZV strain, besides lacking cytotoxicity. However, the application of phosphonodiamidate prodrug strategy did not lead to a boost in antiviral activity.

Synthesis of new 1′(N)-homocarbanucleosides based on 1-methylcyclopenta[c]pyrazole scaffold

A series of 1′-homocarbanucleosides was prepared by coupling a purine or pyrimidine to, or constructing it on, a protected 1-methylcyclopenta[c] pyrazole pseudosugar synthesized from (±)-(exo,exo)-1-methyl-4,5,6,7- tetrahydro-4,7-methanoindazole-5,6-diol

A short and novel synthesis of carbocyclic nucleosides and 4′-epi-carbocyclic nucleosides from 2-cyclopenten-1-ones

Carbocyclic nucleoside analogues remain interesting target molecules having the potential to combine biological activity with greater metabolic stability than their sugar counterparts. This paper describes a rapid and versatile synthetic approach to such

Derivatives with uracil-benzothiazole structure, preparation method of derivatives, and application of anti-HCV drugs

According to the invention, a new series of uracil-benzothiazole NS5B RdRp inhibitors are designed and synthesized; the compounds have the structure shown in a general formula (1), wherein the uracil-benzothiazole NS5B RdRp inhibitor provided by the inven

Synthesis, antiviral, cytotoxic and cytostatic evaluation of N1-(Phosphonoalkyl)uracil derivatives

A series of N1-(phosphonoalkyl)uracils was prepared in a two-step reaction sequence from x- aminoalkylphosphonates and (E)-3-ethoxyacryloyl isocyanate followed by the uracil ring closure. Under standard conditions (NCS; NBS; I2/CAN) all N1-(phosphonoalkyl)uracils were transformed into the respective 5-halogeno derivatives to be later benzoylated at N3. All compounds were evaluated in vitro for activity against a broad variety of DNA and RNA viruses. One compound was slightly active against human cytomegalovirus in HEL cell cultures (EC50 = 45 μM) while another showed weak activity against varicella-zoster virus (TK+ VZV strain OKA and TK- VZV strain 07-1) with EC50 = 43 and 53 μM, respectively. In addition, several compounds exhibited noticeable inhibitory effects on the proliferation of human cervical carcinoma cells (HeLa) at a concentration lower than 200 μM.