6191-99-7Relevant articles and documents
Two birds with one stone: The detection of nerve agents and AChE activity with an ICT-ESIPT-based fluorescence sensor
Meng, Wenqi,Pei, Zhipeng,Wang, Yurun,Sun, Mingxue,Xu, Qingqiang,Cen, Jinfeng,Guo, Kai,Xiao, Kai,Li, Zhenjiang
, (2021)
Nerve agents are among the world's deadliest poisons, and the target enzyme is acetylcholinesterase (AChE). To better diagnosis nerve agent poisonings, a reliable diagnostic method for both nerve agents and AChE is desirable. Herein, we synthesized a series of fluorescent sensors for both real nerve agents and acetylcholinesterase activity detection. Among these sensors, HBQ-AE exhibited a fast response rate (within 10 s for nerve agent and 8 min for AChE), good sensitivity (the limit of detection is 6 nM and 0.2 U/mL) and a high off/on contrast. To the best of our knowledge, HBQ-AE is the first fluorescence sensor for nerve agents and AChE activity detection. The fluorescent change of HBQ-AE from nonfluorescence to blue fluorescence (nerve agent) or orange fluorescence (AChE) by excitation at 365 nm can be easily observed with the naked eye. HBQ-AE was successfully applied to image nerve agents and AChE activity in living cells. Moreover, HBQ-AE is the vital member to construct a test paper that can be employed to detect and diagnose chemical warfare agents.
UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE
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, (2020/04/24)
Described herein is a compound of Formula (I), and pharmaceutically acceptable salts thereof. Also described herein are compositions and the use of such compositions in methods of treating a variety of diseases and conditions, in particular Krabbe's Disease (KD) and Metachromatic leukodystrophy (MLD).
Pyrimidine quinoline derivatives, and preparation method and applications thereof
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Paragraph 0159-0163, (2019/10/01)
The invention discloses pyrimidine quinoline derivatives, a prodrug, and preparation method and applications thereof. The structure of the pyrimidine quinoline derivatives is represented by formula I, wherein R1 is used for representing hydrogen, C1-4 alkyl, C1-4 halogenated alkyl, C4-7 heterocyclic aryl, C4-7 substituted heterocyclic aryl, benzyl, or substituted benzyl, glycosyl, and amino acid; R2, R3, R4, and R5 are used for independently representing hydrogen, C1-4 alkyl, C1-4 alkyloxy, hydroxyl, amino, or substituted amino, C1-4 halogenated alkyl or halogen, glycosyl, and amino acid; R6 is used for representing substituted or non-substituted five-membered heterocycle, substituted or non-substituted six-membered heterocycle, substituted or non-substituted C8-12 fused heterocycle. The pyrimidine quinoline derivatives possess excellent inhibition effect on five kinds of cancer cells, the inhibition IC50 value of most compounds is lower than 20M, the IC50 value of a part of the compounds is even lower than 5M, the inhibition effect is extremely obvious, and the compounds can be prepared into anti-tumor drugs for applications.
