1159977-12-4Relevant academic research and scientific papers
A Practical and Efficient Synthesis of (±)-Anatabine
Rossi, Federico V.,Ballini, Roberto,Barboni, Luciano,Allegrini, Pietro,Palmieri, Alessandro
, p. 1921 - 1925 (2018)
A new efficient synthesis of racemic anatabine is reported. The title target was obtained in an excellent overall yield of 70%, by a five-step synthesis, using cheap reagents and mild reaction conditions.
Preparation method for anatabine
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Paragraph 0021; 0027; 0028; 0036; 0037; 0045; 0046, (2017/11/04)
The invention discloses a preparation method for anatabine. The method comprises the steps of (1) enabling 3-amino methyl pyridine to react with benzophenone to obtain an intermediate 1; (2) synthesizing an intermediate 2 by the intermediate 1 and cis-1,4-dichloro-2-butene; (3) enabling the intermediate 2 to react with Boc anhydride to obtain an intermediate 3; and (4) removing a Boc group from the intermediate 3 to obtain an intermediate 4 to obtain an anatabine product. The anatabine prepared by adopting the method is high in yield, high in purity and good in quality.
