115998-04-4

Upstream product

• 3111-60-2 2-[1-(4-chlorophenyl)ethylidene]malononitrile 
• 99-91-2 para-chloroacetophenone 
• 109-77-3 malononitrile 

Downstream Products

• 115998-23-7 2-Amino-1,4-bis-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 
• 115998-22-6 2-Amino-4-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile 
• 115998-25-9 2-Amino-4-(4-chloro-phenyl)-1-(4-iodo-phenyl)-1H-pyrrole-3-carbonitrile 
• 243665-85-2 2-amino-4-(4-chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrrole-3-carbonitrile 
• 243666-10-6 [7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 243665-92-1 4-amino-7-(3-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 243665-98-7 7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 243666-04-8 4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 243666-09-3 [5-(4-chloro-phenyl)-7-(4-fluoro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 243665-91-0 4-amino-5-(4-chlorophenyl)-7-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 243665-97-6 5-(4-chloro-phenyl)-7-(4-fluoro-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 243666-03-7 4-chloro-5-(4-chloro-phenyl)-7-(4-fluoro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 263702-66-5 3-Amino-4-benzoyl-1-(p-chlorophenyl)-5-(phenylsulfonyl)cyclopentadiene-2-carbonitrile 
• 243665-86-3 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

A novel synthesis of sulfone systems as antimicrobial agents

The applicability and synthetic potency of novel reagent, 2-aryl-1,1-dicyano-3-(phenylsulfonyl)propenes 3 to develop an expeditious convenient synthetic route of unique polyfunctionally substituted carbocyclic and heterocyclic sulfone systems is reported. Chemical and spectroscopic evidence for the structures of the newly synthesized compounds are described. Some of the obtained compounds were tested for their antimicrobial activity.

Study of Mechanism of Reduction of 2-Bromo-1-(p-X-phenyl)ethylidenemalonitrile by 1-Benzyl-1,4-dihydronicotinamide and 10-Methyl-9,10-dihydroacridine

The reduction of 2-bromo-1-(p-X-phenyl)ethylidenemalonitrile (X-BPM: X=H, F, Cl, Br, CN) by NADH models BNAH and AcrH2 has been investigated.Based on product analysis, kinetic isotope effect, and free energy relationship, a direct hydride transfer and an