243665-98-7

Upstream product

• 115998-04-4 2-[2-Bromo-1-(4-chloro-phenyl)-ethylidene]-malononitrile 
• 64-18-6 formic acid 
• 243665-86-3 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 

Downstream Products

• 243666-10-6 [7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 1649461-23-3 C₂₁H₁₅Cl₃FN₃O 
• 1649461-24-4 C₂₅H₁₆Cl₂FN₃O 
• 1649461-22-2 C₂₁H₁₆Cl₂FN₃O 
• 243666-04-8 4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis of 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones and their N-alkylation's under phase transfer conditions

5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were synthesized by the cyclocondensation of 1,4-disubstituted 2-amino-3-cyanopyrrole 1 with formic acid. When comparative study of N versus O alkylation of ambident 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 was carried out under liquid-liquid PTC, solid-liquid PTC, and solid-liquid solvent free conditions using various alkylating agents 3, the N-alkylated product 4 were obtained selectively and exclusively.

Synthesis and reactions of fluoroaryl substituted 2-amino-3- cyanopyrroles and pyrrolo[2,3-d]pyrimidines

Some fluoroaryl substituted 2-amino-3-cyanopyrroles 2 were synthesized from the reaction between (2-bromo-1-arylalkylidene)propanedinitriles 1 and fluoroaryl substituted aromatic amines under Gewald reaction condition, which on reaction with formamide and