116-58-5 Usage
Uses
Used in Diagnostic Applications:
20-BETA-DIHYDROCORTISOL is used as a potential non-invasive diagnostic test for transmissible spongiform encephalopathies (TSEs), a group of progressive neurological disorders that affect both humans and animals. The presence of this metabolite in biological samples can provide valuable information for the early detection and monitoring of TSEs, contributing to improved patient care and management.
Used in Endocrinology and Metabolism Research:
As a metabolite of cortisol, 20-BETA-DIHYDROCORTISOL is used in endocrinology and metabolism research to study the effects of stress on the body and the role of glucocorticoids in various physiological processes. This research can lead to a better understanding of the underlying mechanisms of stress-related disorders and the development of novel therapeutic strategies.
Used in Pharmaceutical Industry:
20-BETA-DIHYDROCORTISOL can be used in the pharmaceutical industry for the development of drugs targeting the glucocorticoid receptor, which plays a key role in regulating the body's response to stress and inflammation. By modulating the activity of this receptor, new drugs can be designed to treat a range of conditions, including autoimmune diseases, inflammatory disorders, and certain types of cancer.
Used in Sports Medicine:
In sports medicine, 20-BETA-DIHYDROCORTISOL can be used as a biomarker to monitor the effects of physical stress and training on the body's endocrine system. This information can help athletes and coaches optimize training regimens, improve performance, and prevent overtraining-related injuries.
Used in Veterinary Medicine:
Similar to its application in human medicine, 20-BETA-DIHYDROCORTISOL can be used in veterinary medicine for the diagnosis and management of TSEs in animals, as well as for studying the effects of stress on the health and well-being of animals. This can contribute to the development of more effective treatment strategies and improved animal welfare.
Check Digit Verification of cas no
The CAS Registry Mumber 116-58-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 116-58:
(5*1)+(4*1)+(3*6)+(2*5)+(1*8)=45
45 % 10 = 5
So 116-58-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-18,22,24-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,17-,18+,19-,20-,21-/m0/s1
116-58-5Relevant academic research and scientific papers
Selective acceptorless dehydrogenation and hydrogenation by iridium catalysts enabling facile interconversion of glucocorticoids
Ngo, Anh H.,Adams, Michael J.,Do, Loi H.
, p. 6742 - 6745 (2015/02/19)
An iridium(III) pentamethylcyclopentadienyl catalyst supported by 6,6'-dihydroxy-2,2'-bipyridine displays exquisite selectivity in acceptorless alcohol dehydrogenation of cyclic α,β-unsaturated alcohols over benzylic and aliphatic alcohols under mild aqueous reaction conditions. Hydrogenation of aldehydes and ketones occurs indiscriminately using the same catalyst under hydrogen, although chemoselectivity could be achieved when other potentially reactive carbonyl groups present are sterically inaccessible. This chemistry was demonstrated in the reversible hydrogenation and dehydrogenation of the A ring of glucocorticoids, despite the presence of other alcohol/or carbonyl functionalities in rings C and D. NMR studies suggest that an iridium(III) hydride species is a key intermediate in both hydrogenation and dehydrogenation processes.
