116002-70-1

Basic information

• Product Name: ONDANSETRON
• Synonyms: AKOS NCG1-0013;9-METHYL-3-[(2-METHYLIMIDAZOL-1-YL)METHYL]-2,3-DIHYDRO-1H-CARBAZOL-4-ONE;Ondansetron HCl 2H2O;OndansetronHclDihydrateUspXxiv;OndansetronBase;Ondansetron Hcl 103639-04 / Base;Ondansetron (base and/or unspecified salts);OMEPRAZOLESODIUM
• CAS NO: 116002-70-1
• Molecular Formula: C₁₈H₁₉N₃O
• Molecular Weight: 293.36
• EINECS: 1308068-626-2
• Mol File: 116002-70-1.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• Refractive Index: 1.691
• CAS DataBase Reference: ONDANSETRON(CAS DataBase Reference)
• NIST Chemistry Reference: ONDANSETRON(116002-70-1)
• EPA Substance Registry System: ONDANSETRON(116002-70-1)

Safety Data

• Hazardous Substances Data: 116002-70-1(Hazardous Substances Data)

Usage

Brand name

Zofran (GlaxoSmithKline).

InChI:InChI=1/C17H18N4O/c1-12-18-8-10-20(12)11-21-9-7-15-16(17(21)22)13-5-3-4-6-14(13)19(15)2/h3-6,8,10H,7,9,11H2,1-2H3

Upstream product

• 693-98-1 2-methylimidazole 
• 99614-64-9 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 27387-31-1 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 1630-73-5 N-ethyloxazolidine 
• 20073-50-1 2-(oxazolidin-3-yl)ethanol 
• 51200-87-4 4,4-dimethyl-oxazolidine 
• 60498-72-8 N-(trimethylsilyl)-2-methylimidazole 
• 294863-10-8 ethyl 3-(1-methyl-1H-indol-2-yl)propanoate 
• 88221-09-4 ethyl 3-(1-methyl-1H-indol-2-yl)acrylate 
• 27421-51-8 1-methyl-1H-indole-2-carboxaldehyde 
• 603-76-9 1-methylindole 
• 77-78-1 dimethyl sulfate 
• 99614-14-9 1,2,3,9-Tetrahydro-3-[(2-methyl-1H-imidazolyl-1-yl)methyl]-4H-carbazol-4-one 
• 132659-89-3 3-[(dimethylamine)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one hydrochloride 

Downstream Products

• 99614-01-4 Ondansetron hydrochloride 
• 153139-56-1 3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one 
• 99614-64-9 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one 

Relevant articles and documents

An efficient process of ondansetron synthesis

An efficient and practical two-step synthesis of ondansetron (1) was accomplished from readily available N-methyltetrahydrocarbazolone (2) via direct Mannich a-methylenation and alumina catalyzed Michael addition resulting in a 70% overall yield.

IMIDAZOLYL MODULATORS OF 5-HT3 RECEPTORS

The present invention relates to new imidazolyl modulators of 5-HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof.

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom

The present invention provides a rapid, high-yielding process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one without using a secondary amine as a catalyst, and without using glacial acetic acid as a solvent. The present invention further provides a rapid, high-yielding process for preparing ondansetron from 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one without using alumina as a catalyst.