1160153-01-4Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of conformationally constrained cis-amide HSP90 inhibitors
Duerfeldt, Adam S.,Brandt, Gary E. L.,Blagg, Brian S.J.
, p. 2353 - 2356 (2009)
Conformationally constrained cis-amide chimeric inhibitors of Hsp90 have been synthesized and evaluated for their Hsp90 inhibitory activity. These new compounds exhibited Hsp90 ATPase inhibition and induced Hsp90-dependent client protein degradation in a
