1160184-14-4

Usage

Uses

Used in Organic Synthesis:
2,6-Dibromo-4-iodopyridine is used as a key intermediate in the synthesis of various organic compounds. Its presence of halogens, bromine and iodine, facilitates easy reactions with other compounds, contributing to the creation of a wide range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-Dibromo-4-iodopyridine is used as a building block for the development of new drugs. Its reactivity allows for the formation of diverse molecular structures, which can be crucial in the design of novel therapeutic agents.
Used in Chemical Research:
2,6-Dibromo-4-iodopyridine is employed as a research tool in chemical laboratories. Its reactivity and structural properties make it an interesting subject for studying reaction mechanisms, exploring new synthetic pathways, and understanding the influence of halogens on molecular interactions.
Safety Considerations:
Due to the reactivity of the halogens present in 2,6-Dibromo-4-iodopyridine, it is essential to handle 2,6-DibroMo-4-iodopyridine with care. Proper storage and disposal methods should be implemented to ensure safety and prevent any potential hazards associated with its use.

Upstream product

• 626-05-1 2,6-Dibromopyridine 

Downstream Products

• 337917-94-9 2,6-dibromo-4-phenylpyridine 
• 1291081-25-8 2-bromo-4,6-diphenylpyridine 

Relevant academic research and scientific papers

Excitation Energy-Dependent Branching Dynamics Determines Photostability of Iron(II)-Mesoionic Carbene Complexes

Photoactive metal complexes containing earth-abundant transition metals recently gained interest as photosensitizers in light-driven chemistry. In contrast to the traditionally employed ruthenium or iridium complexes, iron complexes developed to be promising candidates despite the fact that using iron complexes as photosensitizers poses an inherent challenge associated with the low-lying metal-centered states, which are responsible for ultrafast deactivation of the charge-transfer states. Nonetheless, recent developments of strongly σ-donating carbene ligands yielded highly promising systems, in which destabilized metal-centered states resulted in prolonged lifetimes of charge-transfer excited states. In this context, we introduce a series of novel homoleptic Fe-triazolylidene mesoionic carbene complexes. The excited-state properties of the complexes were investigated by time-resolved femtosecond transient absorption spectroscopy and quantum chemical calculations. Pump wavelength-dependent transient absorption reveals the presence of distinct excited-state relaxation pathways. We relate the excitation-wavelength-dependent branching of the excited-state dynamics into various reaction channels to solvent-dependent photodissociation following the population of dissociative metal centered states upon excitation at 400 nm.

TYK-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting TYK2 and treating a disease associated with the undesirable tyk-2 activity (tyk-2 related diseases), a method of using the compounds disclosed herein for treating inflammatory or autoimmune disease, and a pharmaceutical composition comprising the same.

Deprotonative metalation of chloro- and bromopyridines using amido-based bimetallic species and regioselectivity-computed CH acidity relationships

A series of chloro- and bromopyridines have been deprotometalated by using a range of 2,2,6,6-tetramethylpiperidino-based mixed lithium-metal combinations. Whereas lithium-zinc and lithium-cadmium bases afforded different mono- and diiodides after subsequent interception with iodine, complete regioselectivities were observed with the corresponding lithium-copper combination, as demonstrated by subsequent trapping with benzoyl chlorides. The obtained selectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase and as a solution in THF by using the DFT B3LYP method.

New mixed Li/Mg and Li/Mg/Zn amides for the chemoselectlve metallation of arenes and heteroarenes

New mixed Li/Mg and Li/Mg/Zn amides have been synthesized starting from readily prepared secondary amines. They allow a highly chemoselective directed magnesiation or zincation of various polyfunctional aromatics and heteroaromatics. The kinetic basicity, solubility and stability of these new bases have been compared with those of the corresponding 2,2,6,6- tetramethylpiperamide-derived bases. Wiley-VCH Verlag GmbH & Co. KGaA.