1160184-95-1Relevant academic research and scientific papers
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Chen, Austin,Bayly, Christopher,Bezen?on, Olivier,Richard-Bildstein, Sylvia,Dubé, Daniel,Dubé, Laurence,Gagné, Sébastien,Gallant, Michel,Gaudreault, Mireille,Grimm, Erich,Houle, Robert,Lacombe, Patrick,Laliberté, Sébastien,Lévesque, Jean-Fran?ois,Liu, Suzanna,MacDonald, Dwight,Mackay, Bruce,Martin, David,McKay, Dan,Powell, David,Remeň, L'ubo?,Soisson, Stephen,Toulmond, Sylvie
scheme or table, p. 2204 - 2209 (2010/06/19)
The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p
RENIN INHIBITORS
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Page/Page column 21, (2009/07/17)
The present invention relates to piperidinyl-based renin inhibitor compounds having the formula containing amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
