1160184-91-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-bromo-5-(2-methoxyethoxy)benzaldehyde is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of bioactive compounds, contributing to the development of new drugs and pesticides.
Used in Organic Synthesis:
3-bromo-5-(2-methoxyethoxy)benzaldehyde serves as a building block for the preparation of complex organic molecules. Its presence in organic synthesis facilitates the construction of intricate molecular architectures, which are essential in the advancement of organic chemistry and material science.
Used as a Reagent in Organic Reactions:
Due to its chemical properties, 3-bromo-5-(2-methoxyethoxy)benzaldehyde is a useful reagent in various organic reactions. Its versatility makes it a valuable compound for conducting a range of chemical processes, enhancing the efficiency and effectiveness of these reactions.

Upstream product

• 1160184-89-3 1,3-dibromo-5-(2-methoxyethoxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 626-41-5 3,5-dibromophenol 

Downstream Products

• 1160184-95-1 3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzaldehyde 
• 1223461-29-7 C₁₄H₁₈O₄ 
• 1176327-03-9 3-Bromo-5-(2-methoxyethoxy)benzyl methanesulfonate 
• 1176327-04-0 1-bromo-3-(bromomethyl)-5-(2-methoxyethoxy)benzene 
• 1176327-05-1 [3-bromo-5-(2-methoxyethoxy)benzyl](triphenyl)phosphonium bromide 
• 1176327-06-2 tert-butyl 4-[3-bromo-5-(2-methoxyethoxy)benzylidene]piperidine-1-carboxylate 
• 1176327-07-3 tert-butyl 4-[3-bromo-5-(2-methoxyethoxy)benzyl]piperidine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity

We have previously shown that SMP-304, a serotonin uptake inhibitor with weak 5-HT1A partial agonistic activity, may act under high serotonin levels as a 5-HT1A antagonist that improves the onset of paroxetine in the rat swimming test. However, SMP-304 is mostly metabolized by CYP2D6, indicating limited efficacy among individuals and increased side effects. To reduce CYP2D6 metabolic contribution and enhance SERT/5-HT1A binding affinity, we carried out a series of substitutions at the bromine atom in the left part of the benzene ring of SMP-304 and replaced the right part of SMP-304 with a chroman-4-one. This optimization work led to the identification of the antidepressant candidate DSP-1053 as a potent SERT inhibitor with partial 5-HT1A receptor agonistic activity. DSP-1053 showed low CYP2D6 metabolic contribution and a robust increase in serotonin levels in the rat frontal cortex.

BENZYLPIPERIZINE COMPOUND

Disclosed is a benzylpiperizine compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which is useful as a medicinal agent such as an antidepressant agent. (In the formula (1), R1 represents a hydrogen atom or a met

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p

RENIN INHIBITORS

The present invention relates to piperidinyl-based renin inhibitor compounds having the formula containing amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.