1160184-91-7

Basic information

• Product Name: 3-bromo-5-(2-methoxyethoxy)benzaldehyde
• Synonyms: 3-bromo-5-(2-methoxyethoxy)benzaldehyde
• CAS NO: 1160184-91-7
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.09654
• Mol File: 1160184-91-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-bromo-5-(2-methoxyethoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-(2-methoxyethoxy)benzaldehyde(1160184-91-7)
• EPA Substance Registry System: 3-bromo-5-(2-methoxyethoxy)benzaldehyde(1160184-91-7)

Safety Data

• Hazardous Substances Data: 1160184-91-7(Hazardous Substances Data)

Usage

General Description

3-bromo-5-(2-methoxyethoxy)benzaldehyde is a chemical compound with the molecular formula C10H11BrO3. It is a benzaldehyde derivative with a bromine atom and a methoxyethoxy group attached to the benzene ring. 3-bromo-5-(2-methoxyethoxy)benzaldehyde is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential applications in organic synthesis and as a building block for the preparation of complex organic molecules. Additionally, its chemical properties make it a useful reagent in organic reactions, making it a versatile and valuable compound for various chemical processes.

Upstream product

• 626-41-5 3,5-dibromophenol 
• 1160184-89-3 1,3-dibromo-5-(2-methoxyethoxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1176327-07-3 tert-butyl 4-[3-bromo-5-(2-methoxyethoxy)benzyl]piperidine-1-carboxylate 
• 1176327-06-2 tert-butyl 4-[3-bromo-5-(2-methoxyethoxy)benzylidene]piperidine-1-carboxylate 
• 1176327-05-1 [3-bromo-5-(2-methoxyethoxy)benzyl](triphenyl)phosphonium bromide 
• 1176327-04-0 1-bromo-3-(bromomethyl)-5-(2-methoxyethoxy)benzene 
• 1176327-03-9 3-Bromo-5-(2-methoxyethoxy)benzyl methanesulfonate 
• 1223461-29-7 C₁₄H₁₈O₄ 
• 1160184-95-1 3-(2-methoxyethoxy)-5-(3-methoxypropyl)benzaldehyde 

Relevant articles and documents

Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity

We have previously shown that SMP-304, a serotonin uptake inhibitor with weak 5-HT1A partial agonistic activity, may act under high serotonin levels as a 5-HT1A antagonist that improves the onset of paroxetine in the rat swimming test. However, SMP-304 is mostly metabolized by CYP2D6, indicating limited efficacy among individuals and increased side effects. To reduce CYP2D6 metabolic contribution and enhance SERT/5-HT1A binding affinity, we carried out a series of substitutions at the bromine atom in the left part of the benzene ring of SMP-304 and replaced the right part of SMP-304 with a chroman-4-one. This optimization work led to the identification of the antidepressant candidate DSP-1053 as a potent SERT inhibitor with partial 5-HT1A receptor agonistic activity. DSP-1053 showed low CYP2D6 metabolic contribution and a robust increase in serotonin levels in the rat frontal cortex.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p