1160293-58-2

Basic information

• Product Name: 1-Fluoro-2-isopropoxybenzene
• Synonyms: 1-Fluoro-2-isopropoxybenzene
• CAS NO: 1160293-58-2
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814432
• Mol File: 1160293-58-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 189.1±13.0 °C(Predicted)
• Appearance: /
• Density: 1.020±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Fluoro-2-isopropoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-2-isopropoxybenzene(1160293-58-2)
• EPA Substance Registry System: 1-Fluoro-2-isopropoxybenzene(1160293-58-2)

Safety Data

• Hazardous Substances Data: 1160293-58-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong, sweet

Usage

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds; production of specialty chemicals, flavors, and fragrances

Properties

Aromatic, reactive, ability to undergo various chemical reactions, versatile building block for the synthesis of complex molecules

Precautions

Flammability, potential health hazards if not used properly

Upstream product

• 75-30-9 2-iodo-propane 
• 367-12-4 2-fluorophenol 

Downstream Products

• 1160293-59-3 1-bromo-2-fluoro-3-isopropoxybenzene 
• 1160293-61-7 2-fluoro-3-iodoisopropoxybenzene 
• 1204176-39-5 2-fluoro-3-isopropoxybenzaldehyde 

Relevant articles and documents

GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Combined directed remote metalation-transition metal catalyzed cross coupling strategies: The total synthesis of the aglycones of the gilvocarcins V, M, and E and arnottin I

(Chemical Equation Presented) A key directed remote metalation (DreM)-carbamoyl migration strategy was applied in an efficient synthesis of the naturally occurring 6H-naphtho[1,2-b]benzopyran-6-one defucogilvocarcin V (1a, Scheme 11). The required biarylcarbamate 33d was best prepared by a high yielding Suzuki coupling reaction of 31a with the differentially protected trioxygenated naphthalene coupling partner 32d which was synthesized using a selective acylation of a juglone derivative. In the late stages of the synthesis, the triflate 39 served as the common intermediate to install the required C-8 vinyl group of 1a (Stille coupling) as well as the required substituents for the preparation of defucogilvocarcins M (1b) and E (1c). A variety of protecting group strategies were investigated and provided insight into which groups are preferred for the DreM-carbamoyl migration process. The strategic lessons learned from this total synthesis were applied in the successful total synthesis of the structurally similar natural product arnottin I (2).