1160357-99-2Relevant academic research and scientific papers
Discovery of a potent pyrazolopyridine series of γ-secretase modulators
Qin, Jun,Zhou, Wei,Huang, Xianhai,Dhondi, Pawan,Palani, Anandan,Aslanian, Robert,Zhu, Zhaoning,Greenlee, William,Cohen-Williams, Mary,Jones, Nicholas,Hyde, Lynn,Zhang, Lili
, p. 471 - 476 (2011/08/22)
The synthesis and structure-activity relationship of a novel series of pyrazolopyridines are reported. These compounds represent a new class of γ-secretase modulators that demonstrate good in vitro potency in inhibiting Aβ42 production. Example
GAMMA SECRETASE MODULATORS
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Page/Page column 221; 222, (2009/07/17)
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
