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1160376-89-5

N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide

    Cas No: 1160376-89-5

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  • 1160376-89-5 Structure

  • Basic information

    1. Product Name: N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide
    2. Synonyms: N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide
    3. CAS NO:1160376-89-5
    4. Molecular Formula:
    5. Molecular Weight: 576.72
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1160376-89-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide(1160376-89-5)
    11. EPA Substance Registry System: N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide(1160376-89-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1160376-89-5(Hazardous Substances Data)

1160376-89-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1160376-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,3,7 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1160376-89:
(9*1)+(8*1)+(7*6)+(6*0)+(5*3)+(4*7)+(3*6)+(2*8)+(1*9)=145
145 % 10 = 5
So 1160376-89-5 is a valid CAS Registry Number.

1160376-89-5Downstream Products

1160376-89-5Relevant articles and documents

Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity

Diallo, Hawa,Angell, Davina C.,Barnett, Heather A.,Biggadike, Keith,Coe, Diane M.,Cooper, Tony W.J.,Craven, Andy,Gray, James R.,House, David,Jack, Torquil I.,Keeling, Steve P.,MacDonald, Simon J.F.,McLay, Iain M.,Oliver, Samuel,Taylor, Simon J.,Uings, Iain J.,Wellaway, Natalie

, p. 1126 - 1133 (2011/04/16)

A novel series of indazole non-steroidal glucocorticoid receptor agonist has been discovered. This series features a sulfonamide central core and meta amides which interact with the extended ligand binding domain. This series has produced some of the most potent and least lipophilic agonists of which we are aware such as 20a (NFκB pIC50 8.3 (100%), c log P 1.9). Certain analogues in this series also display evidence for modulated pharmacology.

N- (2 { [1-PHENYL-1H-INDAZ0L-4-YL] AMINO} PROPYL) -SULFONAMIDE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF INFLAMMATIONS

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Page/Page column 84, (2009/07/17)

The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture o

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