35320-22-0

Basic information

• Product Name: D-Alaninamide
• Synonyms: D-ALANINAMIDE;(2R)-2-AMINOPROPANAMIDE;(2R)-2-Aminopropionamide;PropanaMide, 2-aMino-, (2R)-;(R)-2-AMinopropanaMide
• CAS NO: 35320-22-0
• Molecular Formula: C₃H₈N₂O
• Molecular Weight: 88.11
• Mol File: 35320-22-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 74-76 °C
• Boiling Point: 247.433 °C at 760 mmHg
• Flash Point: 103.444 °C
• Appearance: /
• Density: 1.063 g/cm³
• Vapor Pressure: 0.0257mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.99±0.50(Predicted)
• CAS DataBase Reference: D-Alaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: D-Alaninamide(35320-22-0)
• EPA Substance Registry System: D-Alaninamide(35320-22-0)

Safety Data

• Hazardous Substances Data: 35320-22-0(Hazardous Substances Data)

Usage

Uses

(R)-2-Aminopropanamide is a useful reagent for the synthesis of peptides.

InChI:InChI=1/C3H8N2O/c1-2(4)3(5)6/h2H,4H2,1H3,(H2,5,6)/t2-/m1/s1

Upstream product

• 51806-98-5 2-aminopropanenitrile 
• 80222-96-4 2-aminopropanamide hydrochloride 
• 338-69-2 D-Alanine 
• 7625-53-8 D-alanine methyl ester 
• 78981-25-6 N-(tert-butoxycarbonyl)-D-alanine amide 
• 14316-06-4 D-alanine methyl ester hydrochloride 

Downstream Products

• 876293-25-3 ((R)-1-Carbamoyl-ethyl)-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester 
• 19838-07-4 3-methyl-2-hydroxypyrazine 
• 1415380-34-5 2-[2-[(3R)-benzyl-3-[2-(tert-butoxycarbonylamino)-(2R)-propanamido]-2-oxoazetidin1-yl]-2-methylpropanamido]-(2R)-propanamide 
• 1415380-37-8 2-[2-[(3R)-benzyl-3-[2-(tert-butoxycarbonylamino)-(2S)-propanamido]2-oxoazetidin1-yl]-2-methylpropanamido]-(2R)-propanamide 
• 95713-52-3 Nα-(2,4-dinitro-5-fluorophenyl)-D-alaninamide 
• 1570061-44-7 Ac-L-Tyr(Me)-D-Ala-NH₂ 
• 1570061-42-5 Ac-L-Tyr(Me)-L-Ala-NH₂ 
• 1429301-65-4 C₁₁H₂₁N₃O₄ 
• 1333426-88-2 C₃H₆N₄O 
• 1262847-74-4 N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide 
• 1333340-85-4 C₂₃H₂₇N₅O₂ 
• 1262847-67-5 N-((R)-1-carbamoylethyl)-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide 
• 1274687-08-9 C₂₄H₃₀N₆O₄S 
• 1160376-89-5 N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-{6-methyl-4-[((2S)-2-{[(2,4,6-trimethylphenyl)sulfonyl]amino}propyl)amino]-1H-indazol-1-yl}benzamide 

Relevant articles and documents

Mechanistic Insight into the Origin of Stereoselectivity in the Ribose-Mediated Strecker Synthesis of Alanine

Enantioenriched amino acids are produced in a hydrolytic kinetic resolution of racemic aminonitriles mediated by chiral pentose sugars. Experimental kinetic and spectroscopic results combined with DFT computational studies and microkinetic modeling help to identify the nature of the intermediate species and provide insight into the stereoselectivity of their hydrolysis in the prebiotically relevant ribose-alanine system. These studies support a synergistic role for sugars and amino acids in the emergence of homochirality in biological molecules.

Peptides having antiangiogenic activity

Peptides of formula (I) Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11??(I), are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.