116039-49-7

Upstream product

• 115-76-4 2,2-diethyl-1,3-propanediol 
• 51762-67-5 3-nitrobenzene-1,2-dicarbonitrile 

Downstream Products

• 164580-83-0 3-[1-(trimethylsilyl)ethoxy]-phthalonitrile 
• 164580-84-1 3-[3-(trimethylsilyl)propoxy]phthalonitrile 
• 19056-23-6 3-methoxybenzene-1,2-dicarbonitrile 
• 164580-80-7 3-(trimethylsilylmethoxy)-phthalonitrile 
• 769970-45-8 copper tetra-3-(4-undecyloxybenzoyloxy)phthalocyanine 
• 310396-99-7 trifluoromethanesulfonic acid 2,3-dicyanophenyl 
• 601-97-8 3-hydroxyphthalic acid 
• 37418-88-5 3-hydroxyphthalic anhydride 
• 91-15-6 phthalonitrile 

Relevant academic research and scientific papers

Highly selective red-emitting H2S fluorescent probe with a large Stokes shift

The O-2,4-dinitrobenzensulfonate of 1,3-bis(bispyridin-2ylimino)isoindolin-4-ol has been developed as a novel red-emitting fluorescent probe for the detection of H2S. The dinitrobenzenesulfonate moiety in the probe both prohibits the excited st

An ESIPT-based fluorescent probe for sensitive and selective detection of Cys/Hcy over GSH with a red emission and a large Stokes shift

An ESIPT-based fluorescent probe (Probe 1) using acrylate as recognition group for the selective and sensitive detection of cysteine/homocysteine (Cys/Hcy) has been developed. In the presence of Cys/Hcy, this probe was transformed into 1,3-bis(bispyridin-

OLIGONUCLEOTIDE-BASED PROTEOLYSIS TARGETING CHIMERA

Disclosed herein, inter alia, are oligonucleotide-based proteolysis targeting chimeras and methods of use thereof.

A recognition cysteine and homocysteine novel fluorescent probe synthesis and application of

The invention relates to a preparation method and application of a fluorescent probe for detecting cysteine and homocysteine, belonging to the technical field of chemical analysis and detection. The molecular structure is disclosed in the specification. T

A hydroxy benzoic anhydride preparation method

The invention discloses a preparation method of hydroxy benzene anhydride. The preparation method comprises the following steps: mixing nitrophthalonitrile and an organic solvent, adding alkali and nitrite, performing heating and a reflux reaction, and performing aftertreatment so as to obtain hydroxyl phthalonitrile; mixing the hydroxyl phthalonitrile and a KOH aqueous solution, performing heating, reflux and filtration, collecting filtrate, after the filtrate is cooled, regulating the pH to be 1, performing multiple extraction, taking an extraction liquid, and performing aftertreatment so as to obtain hydroxyl phthalic acid; and finally performing vacuum sublimation on the hydroxyl phthalic acid so as to obtain the hydroxy benzene anhydride. The simple preparation method of the hydroxy benzene anhydride, provided by the invention, is mild in reaction conditions, simple and convenient to operate, easy to control, low in equipment requirements and very high in yield.

Synthesis and application of novel fluorescence probe for detecting hydrogen peroxide

The invention discloses a fluorescence probe for detecting hydrogen peroxide, as well as a preparation method and application of the fluorescence probe. The chemical structural formula of the fluorescence probe is as shown in the specification. The raw ma

Synthesis and characterization of monoisomeric 1,8,15,22-substituted (A3B and A2B2) phthalocyanines and phthalocyanine-fullerene dyads

(Figure presented) Synthesis and characterization of three phthalocyanine-fullerene (Pc-C60) dyads, corresponding monoisomeric phthalocyanines (Pc), and building blocks, phthalonitriles, are described. Six novel bisaryl phthalonitriles were prepared by the Suzuki-Miyaura coupling reaction from trifluoromethanesulfonic acid 2,3-dicyanophenyl ester and various oxaborolanes. Two phthalonitriles were selected for the synthesis of A 3B- and A2B2-type phthalocyanines. Phthalonitrile 4 has a bulky 3,5-di-tert-butylphenyl substituent at the α-phthalo position, which forces only one regioisomer to form and greatly increases the solubility of phthalocyanine. Phthalonitrile 8 has a 3-phenylpropanol side chain at the α-position making further modifications of the side group possible. Synthesized monoisomeric A3B- and A 2B2-type phthalocyanines are modified by attachment of malonic residues. Finally, fullerene is covalently linked to phthalocyanine with one or two malonic bridges to produce Pc-C60 dyads. Due to the monoisomeric structure and increased solubility of phthalocyanines, the quality of NMR spectra of the compounds is enhanced significantly, making detailed NMR analysis of the structures possible. The synthesized dyads have different orientations of phthalocyanine and fullerene, which strongly influence the electron transfer (ET) from phthalocyanine to fullerene moiety. Fluorescence quenchings of the dyads were measured in both polar and nonpolar solvents, and in all cases, the quenching was more efficient in the polar environment. As expected, most efficient fluorescence quenching was observed for dyad 20b, with two linkers and phthalocyanine and fullerene in face-to-face orientation.

Phthalocyanines Containing Silicons in Their Peripheral Substituent Groups

Some phthalonitriles and 1H-isoindole-1,3(2H)-diimines containing silicon(s) in their alkoxy substituent groups are prepared and used for phthalocyanine formation reactions. Silicon-carbon bonds often survive under the reaction conditions using K2CO3 in N,N-dimethylformamide (DMF), but are often broken in the presence of sodium hydride. Silicons in the alkoxy groups do not affect the electronic absorption spectra of phthalocyanines in solution significantly. The Q band of films of phthalocyanines (Pcs) with alkyl or alkoxy groups attached to benzene carbons furthest from the Pc core lies to the blue compared to the Pcs in solution, while films of Pcs with eight alkoxy groups closest to Pc core have a Q band shifted to the red.

Use of bisphthalonitriles in the synthesis of side-strapped 1,11,15,25-tetrasubstituted phthalocyanines

Nucleophilic aromatic substitution reactions of 3-nitrophthalonitrile yield 3-hydroxyphthalonitrile and 3-neopentoxyphthalonitrile, the latter of which condensed to 1,8,15,22-tetraneopentoxyphthalocyanine as a mixture of isomers. Bisphthalonitriles such a