1160430-87-4 Usage
Description
4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester is an organic compound that serves as a versatile building block in the synthesis of pharmaceuticals and agrochemicals. It is a derivative of boronic acid featuring a pinacol ester functional group, which endows it with the ability to participate in cross-coupling reactions and Suzuki-Miyaura coupling. 4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester's boronic acid component facilitates the selective and mild formation of carbon-carbon bonds, while the pinacol ester group enhances its stability and solubility. This makes 4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester a valuable reagent in medicinal chemistry for the creation of diverse chemical structures and the development of new drug candidates.
Uses
Used in Pharmaceutical Industry:
4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its ability to form carbon-carbon bonds selectively and under mild conditions makes it an ideal candidate for constructing complex molecular structures that can exhibit therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical field, 4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester is utilized as a key component in the synthesis of new agrochemicals. Its reactivity in cross-coupling reactions allows for the creation of novel molecules with potential applications in pest control and crop protection.
Used in Medicinal Chemistry Research:
4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester is employed as a research tool in medicinal chemistry to explore new chemical space and identify potential drug candidates. Its versatility in forming carbon-carbon bonds and its stability make it a preferred choice for the synthesis of diverse chemical libraries for high-throughput screening.
Used in Organic Synthesis:
As a boronic acid derivative with a pinacol ester functional group, 4-(Hydroxymethyl)-3-methylphenylboronic Acid Pinacol Ester is used in organic synthesis to construct various organic molecules. Its reactivity in cross-coupling reactions and Suzuki-Miyaura coupling provides a mild and selective method for carbon-carbon bond formation, which is crucial for the synthesis of complex organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1160430-87-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,4,3 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1160430-87:
(9*1)+(8*1)+(7*6)+(6*0)+(5*4)+(4*3)+(3*0)+(2*8)+(1*7)=114
114 % 10 = 4
So 1160430-87-4 is a valid CAS Registry Number.
1160430-87-4Relevant articles and documents
PYRROLIDINE GLYCOSIDASE INHIBITORS
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Page/Page column 157, (2020/03/15)
Compounds of formula (I) wherein A, W, R3b, Z and p have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation
Mihai, Madalina T.,Williams, Benjamin D.,Phipps, Robert J.
, p. 15477 - 15482 (2019/10/11)
The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Iridium-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. We describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcohols) and uses standard borylation ligands. Our strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a tetrabutylammonium cation. We hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.
PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
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Page/Page column 40, (2010/04/03)
Disclosed are compounds of formula (I) and or salts thereof which activate soluble guanylate cyclase (sGC), pharmaceutical compositions containing them, their use in the manufacture of a medicament for teating cardiovascular diseases, and processes for their preparation.
