1160478-78-3Relevant articles and documents
Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents
Jeedimalla, Nagalakshmi,Flint, Madison,Smith, Lyndsay,Haces, Alberto,Minond, Dmitriy,Roche, Stéphane P.
, p. 167 - 179 (2015/11/17)
The aim of this study was the synthesis and lead structure selection of a best anti-leukemic agent from a library of aza-podophyllotoxin analogues (APTs). To this end, we report a scalable, modified multicomponent reaction using a "sacrificial" aniline pa