2217-43-8

Basic information

• Product Name: 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO-
• Synonyms: 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO-;5,6,7,8-TETRAHYDRONAPHTHYLENE-2-AMINE;5,6,7,8-TETRAHYDRONAPHTHALEN-2-AMINE;6-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE;5,6,7,8-tetrahydro-2-naphthylamine;(5,6,7,8-Tetrahydronaphthalen-2-yl)amine, 2-Amino-5,6,7,8-tetrahydronaphthalene, 6-Amino-1,2,3,4-tetrahydronaphthalene, 6-Aminotetralin;5,6,7,8-Tetrahydro-2-naphthalenamine;ar-β-Naphthylamine
• CAS NO: 2217-43-8
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• EINECS: 218-714-8
• Product Categories: Amines;Building Blocks;C10;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 2217-43-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 34-38 °C
• Boiling Point: 110 °C/5 mmHg
• Flash Point: 140.8 °C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.00225mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.13±0.20(Predicted)
• CAS DataBase Reference: 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO-(2217-43-8)
• EPA Substance Registry System: 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO-(2217-43-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2217-43-8(Hazardous Substances Data)

Usage

General Description

2-Naphthalenamine, 5,6,7,8-tetrahydro-, also known as 4,5,6,7-tetrahydro-2-naphthylamine, is a chemical compound with the molecular formula C10H13N. It is a white to light brown solid that is insoluble in water but soluble in organic solvents. This chemical is mainly used as an intermediate in the production of dyes, pigments, and pharmaceuticals. It is also utilized in the synthesis of other organic compounds. However, 2-naphthalenamine, 5,6,7,8-tetrahydro- is considered to be potentially hazardous to human health and the environment, as it is classified as a possible human carcinogen and may cause skin and eye irritation. Therefore, proper handling and storage of this chemical are essential to prevent any adverse effects.

InChI:InChI=1/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h5-7H,1-4,11H2

Upstream product

• 91-59-8 naphthalen-2-ylamine 
• 19353-86-7 6-nitrotetralin 
• 4423-74-9 2-formamidonaphthalene 
• 91-17-8 decalin 
• 64-17-5 ethanol 
• 13407-63-1 5,6,7,8-tetrahydro-[2]naphthamide 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 119-64-2 tetralin 
• 7439-89-6 iron 
• 90-15-3 α-naphthol 
• 1821-12-1 4-Phenylbutyric acid 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 40353-34-2 7-nitro-3,4-dihydro-2H-naphthalen-1-one 
• 3470-53-9 6-amino-1-tetralone 

Downstream Products

• 101734-39-8 N-(5,6,7,8-tetrahydro-[2]naphthyl)-phthalamic acid 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 101584-78-5 N-(5,6,7,8-tetrahydro-[2]naphthyl)-toluene-4-sulfonamide 
• 130728-38-0 N-(3-nitro-5,6,7,8-tetrahydro-[2]naphthyl)-toluene-4-sulfonamide 
• 101879-25-8 N-(1,3-dinitro-5,6,7,8-tetrahydro-[2]naphthyl)-toluene-4-sulfonamide 
• 109394-58-3 N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide 
• 1160478-78-3 11-(3,4,5-trimethoxyphenyl)-6,7,8,9-tetrahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one 
• 1240173-45-8 11-(3,4,5-trimethoxyphenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one 
• 1309571-63-8 11-(3,5-dibromophenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one 
• 13909-32-5 C₁₃H₁₆ClN₃O₂ 
• 342043-42-9 2-amino-1-nitro-5,6,7,8-tetrahydronaphthalene 
• 56163-17-8 5,6,7,8-tetrahydronaphthalene-2,3-diamine 
• 408310-39-4 N-(3-chloroacetyl-5,6,7,8-tetrahydro-[2]naphthyl)-acetamide 
• 226-97-1 dibenzo[b,h]acridine 

Relevant articles and documents

A convenient Hofmann reaction of carboxamides and cyclic imides mediated by trihaloisocyanuric acids

A simple, efficient and pot-economic approach in a single vessel has been developed for conversion of aromatic and aliphatic carboxamides into primary amines with one fewer carbom atom (Hofmann reaction) in 38–89 % yield by reacting with trichloro- or tribromoisocyanuric acid and sodium hydroxide in aqueous acetonitrile. Under the same reaction conditions, cyclic imides gave amino acids (69–83 %). The role of the trihaloisocyanuric acids is the in situ generation of N-haloamides, key-intermediates for the Hofmann reaction. The scalability of the methodology was demonstrated by a multigram-scale transformation of phthalimide into anthranilic acid in 77 % yield.

C-H Amination of Arenes with Hydroxylamine

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.