2217-43-8

Usage

Uses

Used in Chemical Synthesis Industry:
2-Naphthalenamine, 5,6,7,8-tetrahydrois used as a chemical intermediate for the production of dyes and pigments, contributing to the coloration and appearance of various products. Its role in this industry is crucial for creating a wide range of colorants used in different applications.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Naphthalenamine, 5,6,7,8-tetrahydroserves as an intermediate in the synthesis of certain medications, playing a vital part in the development of new drugs and therapeutic agents.
Used in Organic Compounds Synthesis:
2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDROis also utilized in the synthesis of other organic compounds, broadening its applications across various chemical and industrial processes that require specific organic molecules for their functionality or production.

InChI:InChI=1/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h5-7H,1-4,11H2

Upstream product

• 581-97-5 2-acetylaminonaphthalene 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 22009-40-1 7-amino-1-tetralone 
• 91-59-8 naphthalen-2-ylamine 
• 19353-86-7 6-nitrotetralin 
• 4423-74-9 2-formamidonaphthalene 
• 91-17-8 decalin 
• 64-17-5 ethanol 
• 7647-01-0 hydrogenchloride 
• 3470-53-9 6-amino-1-tetralone 
• 119-64-2 tetralin 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 18271-22-2 N-(naphthalen-2-yl)benzamide 
• 29809-14-1 5-nitro-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 101734-39-8 N-(5,6,7,8-tetrahydro-[2]naphthyl)-phthalamic acid 
• 109394-58-3 N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide 
• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 13908-56-0 1-(2-chloroethyl)-3-(5,6,7,8-tetrahydro-2-naphthyl)-urea 
• 1076-26-2 1-methyl-2-naphthol 
• 63021-15-8 9,10,11,12-tetrahydro-dibenz[a,i]acridine 
• 105467-77-4 1,2,3,4-tetrahydrodibenzacridine 
• 138848-82-5 [(S)-5-tert-Butoxycarbonylamino-5-(5,6,7,8-tetrahydro-naphthalen-2-ylcarbamoyl)-pentyl]-carbamic acid benzyl ester 
• 124-04-9 Adipic acid 
• 226-92-6 Dibenz[a,i]acridine 
• 226-97-1 dibenzo[b,h]acridine 
• 408310-39-4 N-(3-chloroacetyl-5,6,7,8-tetrahydro-[2]naphthyl)-acetamide 
• 1309571-63-8 11-(3,5-dibromophenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one 
• 1240173-45-8 11-(3,4,5-trimethoxyphenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one 

Relevant academic research and scientific papers

A convenient Hofmann reaction of carboxamides and cyclic imides mediated by trihaloisocyanuric acids

A simple, efficient and pot-economic approach in a single vessel has been developed for conversion of aromatic and aliphatic carboxamides into primary amines with one fewer carbom atom (Hofmann reaction) in 38–89 % yield by reacting with trichloro- or tribromoisocyanuric acid and sodium hydroxide in aqueous acetonitrile. Under the same reaction conditions, cyclic imides gave amino acids (69–83 %). The role of the trihaloisocyanuric acids is the in situ generation of N-haloamides, key-intermediates for the Hofmann reaction. The scalability of the methodology was demonstrated by a multigram-scale transformation of phthalimide into anthranilic acid in 77 % yield.

Quinoxaline compound, preparation method and application of quinoxaline compound in medicine

The invention provides a quinoxaline compound, a preparation method and application of the quinoxaline compound in medicine, and particularly relates to a quinoxaline compound with PAR4 antagonistic activity, a preparation method of the quinoxaline compound, a pharmaceutical composition containing the quinoxaline compound and application of the quinoxaline compound. Specifically, the invention provides a compound shown as a general formula I and/or II or a tautomer or pharmaceutically acceptable salt thereof, a preparation method of the compound, and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicines for preventing and/or treating thromboembolic diseases.

C-H Amination of Arenes with Hydroxylamine

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.

Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives

Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.

A process for the preparation of the compound naphthylamine of process (by machine translation)

The present invention provides a process for preparing compound naphthylamine process method, characterized in that the polarity of the naphthylamine compound dissolved in a solvent proton gender, added with an auxiliary agent, said assistant agent amount is the quality of the states naphthalene amine compound 0.05 - 0.25 times, in order to Ni as the catalyst, hydrogenation reaction at room temperature, after the reaction, filtration, concentration to obtain a tetrahydronaphthalene compounds, the naphthylamine compound of the formula I as shown in the structural formula: the tetrahydronaphthalene amine structural formula of the compound is shown as formula (II) is shown. The reaction of this invention is completed at room temperature, greatly reduced the production energy consumption. At the same time, the reaction almost in the neutral condition, system conditions apply to acid, alkali, heat sensitive all substrate, wide range of application. In addition, because the reaction of the hydrogen pressure is atmospheric, the need to use a high-pressure autoclave equipment, thereby reducing the safety factor in the production process, and reduces equipment investment, greatly reduce the production cost, and is suitable for large-scale industrial production. (by machine translation)

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.

Electrochemical Amination of Less-Activated Alkylated Arenes Using Boron-Doped Diamond Anodes

The anodic C-H amination of aromatic compounds is a powerful and versatile method for the synthesis of aniline derivatives. By using boron-doped diamond (BDD) anodes, a method initially described by Yoshida et al. for electron-rich arenes was expanded to less-activated aromatic systems e.g., simple alkylated benzene derivatives. Anodes based on sp3 carbon seem to be the key for the electrochemical amination reaction. The corresponding primary anilines are obtained in good yields. Despite the cationic intermediates of the electrolytic reaction tert-butyl moieties are tolerated.

Direct and practical synthesis of primary anilines through iron-catalyzed C-H bond amination

The direct C-H amination of arenes is an important strategy to streamline the discovery and preparation of functional molecules. Herein, we report an operationally simple arene C-H amination reaction that, in contrast to most literature precedent, affords directly the synthetically versatile primary aniline products without relying on protecting group manipulations. Inexpensive Fe(II)-sulfate serves as a convenient catalyst for the transformation. The reaction tolerates a wide scope of arenes, including structurally complex drugs. Importantly, the arene substrates are used as limiting reagents in the transformation. This operationally simple transformation should considerably accelerate the discovery of medicines and functional molecules.

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Quenched skeletal Ni as the effective catalyst for selective partial hydrogenation of polycyclic aromatic hydrocarbons

Quenched skeletal Ni is an active and selective catalyst for selective partial hydrogenation of polycyclic aromatic hydrocarbons (PAHs). The molecular structure of PAHs significantly dominate the hydrogenation process and furthermore, the distribution of hydrogenated products.