1160714-36-2Relevant academic research and scientific papers
Novel synthesis and anti-HIV activity of 4′-branched exomethylene carbocyclic nucleosides using a ring-closing metathesis of triene
Li, Hua,Yoo, Jin Cheol,Hong, Joon Hee
experimental part, p. 1238 - 1249 (2009/04/11)
The exomethylene of 6 was successfully constructed from the aldehyde 5 using Eschenmoser′s reagents. A triene compound 7 was cyclized successfully using Grubbs′ II catalyst to give an exomethylene carbocycle nucleus for the target compound. A Mitsunobu reaction was successfully used to condense the natural bases (adenine, thymine, uracil, and cytosine). The synthesized cytosine analogue 20 showed moderate anti-HIV activity (EC50 = 10.67 μM). Copyright Taylor & Francis Group, LLC.
