1160815-55-3

Basic information

• Product Name: 2-methylamino-3,5-dinitro-benzaldehyde
• Synonyms: 2-methylamino-3,5-dinitro-benzaldehyde
• CAS NO: 1160815-55-3
• Molecular Weight: 225.161
• Mol File: 1160815-55-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methylamino-3,5-dinitro-benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylamino-3,5-dinitro-benzaldehyde(1160815-55-3)
• EPA Substance Registry System: 2-methylamino-3,5-dinitro-benzaldehyde(1160815-55-3)

Safety Data

• Hazardous Substances Data: 1160815-55-3(Hazardous Substances Data)

Upstream product

• 91-22-5 quinoline 
• 606-43-9 1-methyl-2-quinolin-2(1H)-one 
• 713124-98-2 2-chloro-3,5-dinitro-benzaldehyde 
• 74-89-5 methylamine 

Relevant articles and documents

Direct amino-halogenation and aziridination of the 2-quinolone framework by sequential treatment of 3-nitro-2-quinolone with amine and N-halosuccinimide

The sequential treatment of 3-nitro-2-quinolones with amines and N-halosuccinimides under mild conditions facilitated the direct amino-halogenation and aziridination at the 4- and 3-positions of the 2-quinolone framework. The selectivity of the functionalization was influenced by the electronic properties of the substituents on the benzene moiety of the nitroquinolone. The electron-withdrawing nitro group promoted the amino-halogenation, and replacement of the nitro group with a halogen or hydrogen markedly increased the selectivity of the aziridination. Moreover, a succinimide group instead of an alkylamino group was introduced at the 4-position, affording the masked form of the 4-amino-3-chloro-2-quinolone derivative. Furthermore, the prepared bis-functionalized quinolones were subjected to Suzuki-Miyaura coupling reaction, ring opening, and hydrazinolysis to afford differently functionalized quinolones.