1160840-15-2Relevant academic research and scientific papers
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives
da Silva Pinto, Ana Cristina,Silva, Luis Francisco Rocha,Cavalcanti, Bruno Coelho,Melo, Marcia Rubia Silva,Chaves, Francisco Celio Maia,Lotufo, Leticia Vera Costa,de Moraes, Manoel Odorico,de Andrade-Neto, Valter Ferreira,Tadei, Wanderli Pedro,Pessoa, Claudia O.,Vieira, Pedro Paulo Ribeiro,Pohlit, Adrian Martin
experimental part, p. 2731 - 2735 (2009/10/09)
4-Nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multigram scale using straight-forward solvent extraction-column chromatography. New semi-synthetic derivatives of 1 were prepared and tested in vitro against multidrug-res
DERIVATIVES OF 4-NEROLIDYLCATECHOL, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESS FOR PRODUCING THE SAME
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Page/Page column 10, (2009/08/14)
The present invention discloses 4-nerolidylcatechol and its derivatives isolated from South American / Amazon plants (Pothomorphe species) and their potential use as therapeutical agent for treatment of malarial symptoms, including malarial patients resistant to traditional drugs. The present invention also discloses a method for producing 4-nerolidylcatechol and their derivatives.
