1160846-47-8Relevant articles and documents
An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System
Cheng, Yi An,Yu, Wesley Zongrong,Yeung, Ying-Yeung
, p. 545 - 552 (2016/01/25)
Reaction between (N,N-dimethylamino)pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.