10041-27-7

Usage

Uses

Used in Pharmaceutical Industry:
(2-METHYL-ALLYLOXY)-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and improve the efficacy of existing ones.
Used in Agrochemical Industry:
(2-METHYL-ALLYLOXY)-ACETIC ACID is used as a vital component in the production of agrochemicals, playing a role in the creation of pesticides and other agricultural products to enhance crop protection and yield.
Used in Chemical Production:
(2-METHYL-ALLYLOXY)-ACETIC ACID is used as a raw material for the manufacturing of plasticizers, resins, and other industrial chemicals, contributing to the versatility and functionality of these products in various applications.

InChI:InChI=1/C6H10O3/c1-5(2)3-9-4-6(7)8/h1,3-4H2,2H3,(H,7,8)

Upstream product

• 79-08-3 bromoacetic acid 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 22874-89-1 ethyl methallyoxyacetate 
• 1068-52-6 sodium 2-bromoacetate 
• 39863-43-9 sodium β-methallyloxide 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1160846-47-8 2-(2-methylallyloxy)-N-tosylacetamide 

Relevant academic research and scientific papers

An improved synthesis of Pyran-3,5-dione: Application to the synthesis of ABT-598, a potassium channel opener, via Hantzsch reaction

Ketoester 1 is cyclized to give pyran-3,5-dione 2 in 78% yield using a parallel addition of ketoester 1 and base NaOtBu in refluxing THF. Compared to the previously reported procedures, these optimized conditions have significantly increased the yield of this transformation and the quality of pyran 2 and prove to be suitable for large-scale preparation. An application of 2 to the synthesis of ABT-598, a potassium channel opener, is demonstrated.

HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES

Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.

Bronsted base-modulated Regioselective Pd-catalyzed intramolecular aerobic oxidative amination of alkenes: Formation of seven-membered amides and evidence for allylic C-H activation

A novel palladium-catalyzed intramolecular aerobic oxidative allylic C-H amination of olefins has been developed. Bronsted base can modulate the regioselectivity, favoring the formation of 7-membered rings. Mechanistic studies using deuterium-labeled substrates as probes support a rate-determining allylic C-H activation/irreversible reductive elimination pathway.

FORMYLTETRAHYDROPYRANS, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF IN THE PRODUCTION OF LIQUID CRYSTAL COMPOUNDS

The invention relates to formyltetrahydropyrans comprising mesogenic substituents, to a method for the production thereof and to the use thereof for producing substituted tetrahydropyran derivatives.

Lewis base-catalyzed [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy carbonyl compounds

Lewis base-catalyzed [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy carbonyl compounds is described. The [2,3]-Wittig rearrangement of silyl enolates generated from α-allyloxy ketones proceeded smoothly by using a Lewis base cataly

Synthesis of α-allyloxy-substituted α,β-unsaturated esters via aldol condensation. Convenient access to highly substituted allyl vinyl ethers

α-Allyloxy-substituted α,β-unsaturated esters 1a-r have been prepared in 5 steps from commercially available starting materials. The key sequence of the synthesis is an aldol addition between an α-allyloxy-substituted ester 2a-i and an aldehyde R1CHO followed by mesylation and DBU mediated elimination to afford the 2-alkoxycarbonyl-substituted allyl vinyl ethers 1a-r. The E/Z ratio of the newly generated vinyl ether double bond is apparently determined by the steric bulk of the vinyl ether double bond substituent R1. Z:E ratios from 3:2-9:1 were obtained.

-WITTIG REARRANGEMENT OF ALLYLIC GLYCOLATE ESTERS VIA BORON AND TIN ENOLATES

Wittig rearrangement of allylic glycolate esters via boron and tin enolates gave diastereoselectivities as high as 99.5 : 0.5.Tin enolates were more stereoselective than boron enolates.