116107-13-2Relevant academic research and scientific papers
Semisynthesis of mallotus B from rottlerin: Evaluation of cytotoxicity and apoptosis-inducing activity
Jain, Shreyans K.,Pathania, Anup S.,Meena, Samdarshi,Sharma, Rajni,Sharma, Ashok,Singh, Baljinder,Gupta, Bishan D.,Bhushan, Shashi,Bharate, Sandip B.,Vishwakarma, Ram A.
, p. 1724 - 1730 (2013/10/22)
Mallotus B (2d) is a prenylated dimeric phloroglucinol compound isolated from Mallotus philippensis. There have been no reports on the synthesis or biological activity of this compound. In the present paper, a semisynthetic preparation of mallotus B is reported via base-mediated intramolecular rearrangement of rottlerin (1), which is one of the major constituents of M. philippensis. The homodimer rottlerone was also formed as one of the products of this base-mediated intramolecular reaction. Rottlerin (1), along with rottlerone (2c) and mallotus B (2d), was evaluated for cytotoxicity against a panel of cancer cell lines including HEPG2, Colo205, MIAPaCa-2, PC-3, and HL-60 cells. Mallotus B (2d) displayed cytotoxicity for MIAPaCa-2 and HL-60 cells with IC50 values of 9 and 16 μM, respectively. Microscopic studies in HL-60 cells indicated that mallotus B (2d) induces cell cycle arrest at the G1 phase and causes defective cell division. It also induces apoptosis, as evidenced by distinct changes in cell morphology.
