1161233-85-7

Basic information

• Product Name: BTZ043
• Synonyms: BTZ043;BTZ043 raceMate;2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one;BTZ 10526043;PBTZ 169
• CAS NO: 1161233-85-7
• Molecular Formula: C₁₇H₁₆F₃N₃O₅S
• Molecular Weight: 431.3862496
• EINECS: -0
• Mol File: 1161233-85-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 547.558 °C at 760 mmHg
• Flash Point: 284.953 °C
• Appearance: /
• Density: 1.68
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• CAS DataBase Reference: BTZ043(CAS DataBase Reference)
• NIST Chemistry Reference: BTZ043(1161233-85-7)
• EPA Substance Registry System: BTZ043(1161233-85-7)

Safety Data

• Hazardous Substances Data: 1161233-85-7(Hazardous Substances Data)

Usage

Uses

BTZ043 is an inhibitor of the essential flavo-enzyme Decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1).

Upstream product

• 4254-15-3 (S)-1,2-Propanediol 
• 1396842-55-9 8-nitro-2-(4-oxopiperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one 
• 1344087-73-5 2‐(methylthio)‐8‐nitro‐6‐(trifluoromethyl)‐1,3‐ benzothiazin‐4‐one 
• 22227-59-4 2-chloro-3-nitro-5-(trifluoromethyl)benzoic acid 
• 87033-30-5 2-chloro-3-nitro-5-(trifluoromethyl)benzoyl chloride 
• 1344087-80-4 (S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decane 
• 41661-47-6 piperidin-4-one 
• 140-89-6 potassium ethyl xanthogenate 
• 22227-47-0 2-chloro-3-nitro-5-(trifluoromethyl)benzamide 

Relevant articles and documents

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis

8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and is applicable for preparation of a wide variety of BTZ analogues. The synthetic procedure furthermore facilitates the replacement of the sulphur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogues were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.

PROCESS FOR THE PREPARATION OF 2-AMINO-SUBSTITUTED 1,3-BENZOTHIAZINE-4-ONES

A process for preparing 2-aminosubstituted 1, 3 -benzothiazine- 4 -ones is provided which comprises the following step: Formula (I) wherein Y is halogen; R is independently selected from C1-6-alkyl which may optionally be substituted by halogen, -NO2, halogen, -CHO -COOR4 (wherein R4 is hydrogen or C1-6-alkyl) and -CN; R3 is C1-6-alkyl which may be substituted by halogen; X is halogen; and n is 0 or an integer of 1 to 4; if n is 2, 3 or 4, multiple Rs may be the same or different.