116137-82-7

Basic information

• Product Name: O(6),7-dimethylguanine
• Synonyms: O(6),7-dimethylguanine
• CAS NO: 116137-82-7
• Molecular Formula: C7H9N5O
• Molecular Weight: 179.17926
• Mol File: 116137-82-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 450.5 °C at 760 mmHg
• Flash Point: 226.3 °C
• Appearance: /
• Density: 1.56 g/cm³
• Vapor Pressure: 2.62E-08mmHg at 25°C
• Refractive Index: 1.729
• PKA: 3.76±0.30(Predicted)
• CAS DataBase Reference: O(6),7-dimethylguanine(CAS DataBase Reference)
• NIST Chemistry Reference: O(6),7-dimethylguanine(116137-82-7)
• EPA Substance Registry System: O(6),7-dimethylguanine(116137-82-7)

Safety Data

• Hazardous Substances Data: 116137-82-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H9N5O/c1-12-3-9-5-4(12)6(13-2)11-7(8)10-5/h3H,1-2H3,(H2,8,10,11)

Upstream product

• 7803-88-5 6-O-methylguanosine 
• 38119-33-4 2-amino-6-chloro-7-methyl-7H-purine 
• 124-41-4 sodium methylate 
• 20535-83-5 O-methylguanine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Formation of O6,7-dimethylguanine residues in calf thymus deoxyribonucleic acid treated with carcinogenic N-methyl-N-nitrosourea in vitro.

Treatment of calf thymus deoxyribonucleic acid (DNA) in vitro with a methylating carcinogen, N-methyl-N-nitrosourea (MNU), in phosphate buffer (pH 7.2) resulted in formation of O6,7-dimethylguanine residues in DNA besides the well-known methylated DNA adducts, 7-methylguanine, O6-methylguanine and 3-methyladenine. The product ratio (%) of O6,7-dimethylguanine versus 7-methylguanine was 0.32 after one MNU treatment. The significance of formation of O6,7-dimethylguanine residues in DNA is discussed briefly in relation to the carcinogenicity of MNU.

Chemical reactivity of alkylguanines. I. Methylation of O6-methylguanine derivatives

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