116141-68-5

Usage

InChI:InChI=1/C8H16O3/c1-8(2)5-10-7(3-4-9)11-6-8/h7,9H,3-6H2,1-2H3

Upstream product

• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 116140-97-7 Ethyl 5,5-dimethyl-1,3-dioxan-2-acetate 
• 116376-29-5 2-<2-(benzyloxy)ethyl>-5,5-dimethyl-1,3-dioxane 

Downstream Products

• 118993-53-6 DL-4,5-di-O-benzyl-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 
• 130633-29-3 <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol 
• 130633-28-2 <2(R)>-L-3-O-benzyl-4,5-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2-O-(phenylethyl)-muco-inositol 
• 130633-29-3 <5(R)>-D-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol 
• 558464-62-3 2-[3-(4-Chlorophenylsulfonyl)-3-(2,5-difluorophenyl)propyl]-5,5-dimethyl-1,3-dioxane 
• 119525-96-1 DL-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate) 
• 119525-96-1 D-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate) 
• 119525-96-1 L-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate) 
• 130633-19-1 DL-4,5-di-0-benzyl-6-0-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1-(dibenzylphosphate) 

Relevant academic research and scientific papers

MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION OF MYO-INOSITOL PHOSPHATES AND RELATED CYCLITOL DERIVATIVES FROM BENZENE.

Pseudomonas putida oxidation of benzene affords cis-3,5-cyclohexadiene-1,2-diol (2) which is used as a novel precursor for the synthesis of D- and L-myo-inositol 1,4,5-triphosphates, (-)-(1) and (+)-(1).The versatility of this approach to functionalised cyclitols is illustrated in the synthesis of myo-inositol 1-phosphate (19), 6-deoxy, 6-deoxy-6-fluoro, and 6-deoxy-6-methyl myo-inositols (31), (37) and (43), and their 1,4,5-trisphosphate derivatives (33), (39) and (45).

Highly Efficient Syntheses of Alkyl 3,3-Dialkoxypropanoates, Alkyl 4-Ethoxy-2-oxo-3-butenoates, and Monoprotected Malonaldehydes

Haloform reaction of 4-alkoxy-1,1,1-trichloro-3-buten-2-ones, which can be obtained by acylation of enol ethers, gives 3,3-dialkoxypropanoic esters.Transacetalization of ethyl 3,3-diethoxypropanoate with 2,2-dimethyl-1,3-propanediol, followed by reduction and oxidation with DMSO/oxalyl chloride yields a monoprotected malonaldehyde. 4-Ethoxy-2-oxo-3-butenoates are synthesized either by acylation of enol ethers with alkoxalyl chlorides or by Claisen condensation of alkyl pyruvates with orthoesters.