1161432-99-0Relevant articles and documents
Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors
Sechi, Mario,Azzena, Ugo,Delussu, Maria Paola,Dallocchio, Roberto,Dessi, Alessandro,Cosseddu, Alessia,Pala, Nicolino,Neamati, Nouri
experimental part, p. 2442 - 2461 (2009/04/05)
HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.