116156-31-1Relevant academic research and scientific papers
HIGHLY EFFICIENT OXAZOLONE-DERIVED REAGENTS FOR BETA-LACTAM FORMATION FROM BETA-AMINO ACIDS
Kunieda, Takehisa,Nagamatsu, Tomohisa,Higuchi, Tsunehiko,Hirobe, Masaaki
, p. 2203 - 2206 (1988)
Based on a unique leaving ability of 2-oxazolone moiety, highly efficient reagents have been developed for the formation of β-lactam compounds from β-amino acids including a facile preparation of penam, a basic skeleton of penicillins.
A NOVEL METHOD FOR THE SYNTHESIS OF β-LACTAMS BY MEANS OF PHASE TRANSFER SYSTEM
Watanabe, Yutaka,Mukaiyama, Teruaki
, p. 443 - 444 (1981)
The reaction of β-amino acids with methanesulfonyl chloride in a chloroform-water bilayer system in the presence of 15 molpercent of tetrabutylammonium hydrogen sulfate gives the corresponding β-lactams in good yields.
