116174-52-8Relevant academic research and scientific papers
Cardiotonic Agents. 7. Prodrug Derivatives Of 4-Ethyl-1,3-dihydro-5--2H-imidazol-2-one
Shaw, Kenneth J.,Erhardt, Paul W.,Hagedorn, Alfred A.,Pease, Cynthia A.,Ingebretsen, William R.,Wiggins, Jay R.
, p. 1267 - 1272 (2007/10/02)
The cardiotonic agent 4-ethyl-1,3-dihydro-5--2H-imidazol-2-one (1) was found to have low bioavailability when administered orally to rats and dogs.A series of N-acyl derivatives, an underutilized prodrug of acidic NH
Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol-2-one, composition containing them, and method of using them to treat cardiac failure
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, (2008/06/13)
Orally active prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one are disclosed. Pharmaceutical formulations containing such compounds are also provided.
