116183-83-6

Basic information

• Product Name: (3S)-(+)-3-Aminopyrrolidine dihydrochloride
• Synonyms: (3S)-pyrrolidin-3-aMine dihydrochloride;(S)-3-AMinopyrroline dihydrochloride;3-Pyrrolidinamine, hydrochloride (1:2), (3S)-;aminopyrrolidinedihydrochloride;PYRROLIDIN-3-YL-AMINE, (S), DIHYDROCHLORIDE;(S)-(+)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE;(S)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE;(S)-PYRROLIDIN-3-AMINE DIHYDROCHLORIDE
• CAS NO: 116183-83-6
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.06
• EINECS: -0
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;Benzenes;3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 116183-83-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 283°C
• Boiling Point: 214.5 °C at 760 mmHg
• Flash Point: 83.5 °C
• Appearance: /
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.1 ° (C=10, H2O)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: very faint turbidity
• Sensitive: Hygroscopic
• BRN: 4870016
• CAS DataBase Reference: (3S)-(+)-3-Aminopyrrolidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-(+)-3-Aminopyrrolidine dihydrochloride(116183-83-6)
• EPA Substance Registry System: (3S)-(+)-3-Aminopyrrolidine dihydrochloride(116183-83-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36-26/37
• Hazardous Substances Data: 116183-83-6(Hazardous Substances Data)

Usage

General Description

(3S)-(+)-3-Aminopyrrolidine dihydrochloride is a chemical compound with the molecular formula C4H11N2 · 2HCl. It is a salt formed from the combination of the amino acid pyrrolidine and two molecules of hydrochloric acid. (3S)-(+)-3-Aminopyrrolidine dihydrochloride is a chiral molecule, meaning it has a specific three-dimensional arrangement of atoms. The (3S)-(+)-3-Aminopyrrolidine dihydrochloride is commonly used in pharmaceutical research and drug development due to its potential applications in synthesizing new medicines. It is also used in chemical reactions and analysis as a chiral auxiliary. Additionally, this compound plays a role in the study and development of new materials and compounds in chemistry.

InChI:InChI=1/C4H10N2.2ClH/c5-4-1-2-6-3-4;;/h4,6H,1-3,5H2;2*1H/t4-;;/m0../s1

Upstream product

• 116183-82-5 (R)-pyrrolidin-3-amine 
• 116143-03-4 (3R)-3-azido-1-(phenylmethyl)pyrrolidine 
• 114636-29-2 (3S)-3-azido-1-(phenylmethyl)pyrrolidine 

Downstream Products

• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 816424-31-4 2-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-3-[(2,4-difluorophenyl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one 
• 181625-29-6 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt 
• 956467-63-3 N-((3R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-pyrrolidinyl)-3,4-bis(methyloxy)benzenesulfonamide 
• 132195-60-9 7-((S)-3-Amino-pyrrolidin-1-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 132195-48-3 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Process for producing 1H-3-aminopyrrolidine and derivatives thereof

A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino-protected aspartic anhydride represented by the formula (1) with a primary amine represented by the formula R'NH2, subjecting the reaction product to cyclodehydration to obtain an optically active 1-aralkyl-3-(protected amino)pyrrolidine-2,5-dione compound represented by the formula (2), subsequently eliminating the protective group from the 3-position amino group of the compound represented by the formula (2) to obtain an optically active 1-aralkyl-3-aminopyrrolidine-2,5-dione compound represented by the formula (3), reducing the carbonyl groups of the compound represented by the formula (3) to obtain either an optically active 1-aralkyl-3-aminopyrrolidine compound represented by the formula (4) or a salt thereof with a protonic acid, and then subjecting the compound represented by the formula (4) or the salt thereof to hydrogenolysis to obtain an optically active 1H-3-aminopyrrolidine or a protonic acid salt thereof.

1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents

There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.