116185-65-0Relevant academic research and scientific papers
Synthesis of the α,β-Diketo Amide Segment of the Novel Immunosuppressive FK506
Williams, D. R.,Benbow, J. W.
, p. 4643 - 4644 (1988)
A convenient synthesis of the optically active subunit 2, incorporating the novel α,β,γ-tricarbonyl system of the potent immunosuppressive macrolide FK506, is described.
Synthesis and analysis of 506BD, a high-affinity ligand for the immunophilin FKBP
Somers, Patricia K.,Wandless, Thomas J.,Schreiber, Stuart L.
, p. 8045 - 8056 (2007/10/02)
The design, synthesis, and analysis of a high-affinity ligand, S06BD, for the human immunophilin FKBP is described. The synthesis illustrates a novel hydroboration reaction that proceeds with unusual regio- and stereochemical control. In accord with expec
