92822-62-3Relevant articles and documents
Synthesis and in vitro biological evaluation of 3-amino-3-deoxydihydrosphingosines and their analogues
Gonda, Jozef,Jáger, Dávid,Kuchár, Juraj,Martinková, Miroslava,Pilátová, Martina Bago,Raschmanová, Jana ?paková
, (2019/12/11)
The stereoselective synthesis of the 3-amino-3-deoxydihydrosphingosines and their isomeric analogues from dimethyl L-tartrate is described by means of [3,3]-sigmatropic rearrangements and the cross metathesis reaction as a cornerstone of the developed str
Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment
Evans, David A.,Burch, Jason D.,Hu, Essa,Jaeschke, Georg
, p. 4671 - 4699 (2008/09/21)
The enantioselective total synthesis of callipeltoside A is described. Two syntheses of the macrolactone subunit are included: the first relies upon an Ireland-Claisen rearrangement to generate the trisubstituted olefin geometry and the second utilizes an enantioselective vinylogous aldol reaction for this purpose. Enantioselective syntheses of the sugar and chlorocyclopropane side chain fragments are also disclosed. The relative and absolute stereochemistry of this natural product was determined by fragment coupling with the two enantiomers of the side chain fragment.
EXPEDITIOUS SYNTHESIS OF DPD
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Page/Page column 13-14, (2008/06/13)
This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi