116228-38-7Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION
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Paragraph 0343; 0344; 0345; 0346; 0347, (2013/08/14)
The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 63, (2008/06/13)
A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
On the Chemistry of Pyrazolylalkines; Pyrazoles II.
Heinisch, Gottfried,Holzer, Wolfgang,Obala, Claudia
, p. 253 - 262 (2007/10/02)
Palladium-catalyzed reactions of 1-benzoyl-4-iodopyrazole (2a) with monosubstituted acetylenes 3a,3b and 3c in triethylamine solution provide convenient access to the cross-coupled products 4a,4b and 4c.The 4-ethinylpyrazoles 5a and 7 obtained after metha
