116236-20-5Relevant academic research and scientific papers
The 2,4,6-Triisopropylbenzenesulfonyl Residue, a New Protecting Group for the Guanidino Function of Arginine
Echner, Hartmut,Voelter, Wolfgang
, p. 1591 - 1594 (2007/10/02)
The 2,4,6-triisopropylbenzenesulfonyl group is introduced in high yield into the guanidino function of arginine by the reaction of Nα-protected arginine with 2,4,6-triisopropylbenzenesulfonyl chloride.This protecting group was found to be cleaved by commonly used reagents used in peptide synthesis like methanesulfonic, trifluoromethanesulfonic acid or mixtures of trifluoroacetic with methanesulfonic or trifluoromethanesulfonic acid. - Keywords: Arginine Protecting Group, Arginine-Containing Peptides, Guanidino Function, Peptide Synthesis
